Molina-Sotomayor, EdgardoCastillo-Quezada, HumbertoMartínez-Salazar, CristianGonzález-Orb, MarceloEspinoza-Salinas, AlexisGonzalez-Jurado, José Antonio2022-06-102022-06-102020-09International Journal of Environmental Research and Public Health Open Access Volume 17, Issue 17, Pages 1 - 171 September 2020 Article number 620316617827https://repositorio.unab.cl/xmlui/handle/ria/22773Indexación: Scopus.The aim of this study was to determine the effects of a muscular strength programme on the levels of insulin-like growth factor-1 (IGF-1) and cognitive status in elder women with mild cognitive impairment who lived in areas of high air pollution. A total of 157 women participated in the study, distributed in four groups: Active/Clean (AC n = 38) and Active/Pollution (AP n = 37), who carried out a progressive resistance training programme for 24 months, and Sedentary/Clean (SC n = 40) and Sedentary/Pollution (SP n = 42). Maximum strength in the upper and lower limbs (1RM), cognition (Mini-Mental Scale Examination (MMSE)) and blood IGF-1 were evaluated. At the beginning of the intervention, there were no differences between the groups in the assessed variables. The active groups which carried out the resistance training programme (AC and AP), registered better results in IGF-1 than the sedentary groups. These differences were statistically significant in AC vs. SC (p < 0.01) and AP vs. SC (p < 0.05). Regarding MMSE, group AC registered the highest score increases (+8.2%) (significantly better than the other groups), while group SP worsened (−7%) significantly compared to the other three groups. In conclusion, resistance training had a positive effect on IGF-1, while sedentary behaviour and air pollution had a negative effect on cognitive status. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.enCognitive impairmentExercisePhysical activitySedentarismStrength muscular environmental healthArtículoAttribution 4.0 International (CC BY 4.0)10.3390/ijerph17176203