Diaz-Toro, FelipeNazar, GabrielaTroncoso, ClaudiaConcha-Cisternas, YenyLeiva-Ordoñez, Ana MariaMartinez-Sanguinetti, Maria AdelaParra-Soto, SolangeLasserre-Laso, NicoleCigarroa, IgorMardones, LorenaVásquez-Gómez, JaimePetermann-Rocha, FannyDiaz-Martinez, XimenaCelis-Morales, Carlos2023-11-302023-11-302023-01International Journal of Environmental Research and Public Health Open Access Volume 20, Issue 2January 2023 Article number 11951661-7827https://repositorio.unab.cl/xmlui/handle/ria/54261Indexación: ScopusWe aimed to investigate the association between frailty status and all-cause mortality in middle-aged and older people. We included 2661 individuals aged ≥ 35 from the Chilean National Health Survey 2009–2010. Mortality was determined through linkage with the Chilean Civil Registry and Identification. A 36-item frailty index (FI) was used to assess the frailty status. Associations between frailty status and all-cause mortality were assessed using Kaplan–Meier and Cox proportional hazard models adjusted for sociodemographic and lifestyle factors. A non-linear association was investigated using penalized cubic splines fitted in the Cox models. During an 8.9 median follow-up (interquartile range of 8.6–9.0), 308 individuals died (11.5%). Lower survival rates were observed in frail individuals compared to pre-frail and robust people (log-rank < 0.001). Compared with robust individuals, frail people had a higher mortality risk (HR: 2.35 [95% CI: 1.57 to 3.51]). Frail middle-aged individuals had a higher risk of dying independently of major risk factors. © 2023 by the authors.enChileFrailtyMiddle-agedMortalityArtículoAtribución 4.0 Internacional (CC BY 4.0)10.3390/ijerph20021195