Bórquez, Daniel A.Urrutia, Pamela J.Wilson, CarlosVan Zundert, BrigitteNúñez, Marco TulioGonzález-Billault, Christian2023-11-092023-11-092016-05Journal of Neurochemistry. Volume 137, Issue 4, Pages 506 - 517. 1 May 20160022-3042https://repositorio.unab.cl/xmlui/handle/ria/53880Indexación: Scopus.The generation of abnormally high levels of reactive oxygen species (ROS) is linked to cellular dysfunction, including neuronal toxicity and neurodegeneration. However, physio logical ROS production modulates redox-sensitive roles of several molecules such as transcription factors, signaling proteins, and cytoskeletal components. Changes in the func tions of redox-sensitive proteins may be important for defining key aspects of stem cell proliferation and differentiation, neuronal maturation, and neuronal plasticity. In neurons, most of the studies have been focused on the pathological impli cations of such modifications and only very recently their essential roles in neuronal development and plasticity has been recognized. In this review, we discuss the participation of NADPH oxidases (NOXs) and a family of protein-methionine sulfoxide oxidases, named molecule interacting with CasLs, as regulated enzymatic sources of ROS production in neurons, and describes the contribution of ROS signaling to neurogenesis and differentiation, neurite outgrowth, and neu ronal plasticity.enNADPH OxidaseMICALReactive Oxygen SpeciesNeural Progenitor CellsNeuronal DifferentiationNMDA ReceptorArtículo10.1111/jnc.13581