Huerta-Uribe, NidiaHormazábal-Aguayo, IgnacioMuñoz-Pardeza, JacintoChueca-Guindulain, María JBerrade-Zubiri, SaraSesma, Carlos AndrésSánchez, Elisabet BurilloEzzatvar, YasminYáñez-Sepúlveda, RodrigoIzquierdo, MikelGarcía-Hermoso, Antonio2025-03-212025-03-212024-12-04BMJ Open Sport and Exercise Medicine Volume 10, Issue 4 4 December 2024 Article number e0021772055-7647https://repositorio.unab.cl/handle/ria/63835Indexación (Scopus)Objective This study aimed to explore the association between handgrip strength, cardiometabolic risk (CMR) and body composition in youth with type 1 diabetes. Methods For this prospective cohort study, muscular fitness was assessed via handgrip test and relativised by weight, and body composition, evaluated through dual-energy X-ray absorptiometry in type 1 diabetes patients aged 6-18 years. CMR score included z-scores for total body fat, blood pressure, glycated haemoglobin (HbA1c), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglyceride-glucose index. Results Eighty-three patients were analysed at baseline and 1-year follow-up (44.6% females, mean age 12.77 years). Individuals with high handgrip strength tended to have lower CMR and body fat compared with those with low handgrip strength. Over a year, individuals with high handgrip strength showed reduced HbA1c, CMR and subcutaneous fat. Consistently meeting high handgrip strength criteria resulted in reductions in HbA1c levels, CMR score and subcutaneous adipose tissue compared with those who never complied or lost compliance during follow-up. Additionally, subjects classified with high handgrip strength both at baseline and follow-up had a lower likelihood of being classified with high CMR (OR=0.241, 95% CI 0.121 to 0.947, p=0.044). Conclusions High handgrip strength was associated with significant cardiometabolic and body composition benefits in youth with type 1 diabetes. This tool could be considered of potential clinical value for incorporating assessments like handgrip tests to monitor and address cardiometabolic health.en-USChildren's health and exerciseDiabetesMusclePhysical fitnessArtículoAtribución/Reconocimiento 4.0 Internacional10.1136/bmjsem-2024-002177