Fuentes, DENavarro, CATantaleán, JCAraya, MASaavedra, CPPérez, JMCalderón, ILYouderian, PAMora, GCVásquez, CC2024-07-032024-07-032005-05-01RESEARCH IN MICROBIOLOGY, Volume 156, Issue 4, Page, 472-4770923-2508https://repositorio.unab.cl/handle/ria/58181INDEXACIÓN: WEB OF SCIENCE.We have characterized a natural isolate of Staphylococcus epidermidis resistant to heavy metals that carries a small 2391-bp plasmid, pSepCH, encoding the qacC gene. The S. epidermidis qacC gene confers resistance to a number of beta-lactam antibiotics and to ethidium bromide in its natural host and in Escherichia coli K12 and Salmonella enterica sv. Typhimurium. This is the first communication of a small multidrug resistance (SMR) pump involved in resistance to beta-lactam antibiotics. Experiments using tolC, ompW and ompD mutant strains of S. Typhimurium demonstrated that the beta-lactam antibiotic resistance conferred by this pump does not depend on these outer membrane proteins. (c) 2005 Elsevier SAS. All rights reserved.enmultidrug resistanceStaphylococcus epidermidisbeta-lactam resistanceethidium bromideSMRArtículoCC BY-NC-ND 4.0 ATRIBUCIÓN-NOCOMERCIAL-SINDERIVADAS 4.0 INTERNACIONAL Deed10.1016/j.resmic.2005.01.002