Marzuca-Nassr, Gabriel NasriPeñailillo, LuisValladares-Ide, DenisseMartinez-Huenchullan, SergioCuri, RuiHirabara, Sandro MassaoVitzel, Kaio Fernando2024-07-292024-07-292023Frontiers in Physiology. Volume 14. 2023. Article number 13335771664-042Xhttps://repositorio.unab.cl/handle/ria/58818Indexación: ScopusFunding: The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The Interuniversity Center for Healthy Aging, Code RED21993, the Coordination for the Improvement of Higher Level/Education Personnel (CAPES), the National Council for Scientific and Technological Development (CNPq), and the São Paulo State Research Foundation (FAPESP, process numbers: 2018/09868-7 and 2022/09341-4) funded this report. We also acknowledge the support from FONDECYT N° 1211962.Introduction: Atrophy of skeletal muscle during aging is a subject of heightened interest for researchers, as the muscle tissue is an essential regulator of whole-body metabolism, bone health, fall prevention, cognitive function, and general wellbeing. Indeed, the precise role of skeletal muscle and strategies to prevent the loss of skeletal muscle mass in individuals aged 60 years or older have been reported (Marzuca-Nassr et al., 2020a; Marzuca-Nassr et al., 2023). For example, previous studies demonstrated that skeletal muscle atrophy caused by aging can be attenuated/prevented using appropriate therapeutic strategies, including different physical exercise modalities, nutritional supplementation, and medications (Marzuca-Nassr et al., 2020b; Cuyul-Vasquez et al., 2023). However, the most appropriate exercise, supplement, or medication, individually or in combination, remains undefined. Thus, identifying the most effective strategies to attenuate or reverse skeletal muscle atrophy in this particular population is crucial. Towards this goal, the Frontiers in Physiology Healthy Aging series Research Topic Spotlight on Aging: Physiology, Prevention, and Management of Skeletal Muscle Atrophy was created. We encouraged researchers investigating the physiology of skeletal muscle atrophy, with an emphasis on the following subjects: skeletal muscle architecture and mechanical properties in older individuals and/or exercise modalities, oral supplements, medications, or other therapeutic alternatives that prevent and/or manage skeletal muscle atrophy, to submit their Original Research, Systematic Review (with or without Meta-analysis), or any other article type within the scope of the journal, section, and Research Topic for consideration for publication in the Healthy Aging series. It is important to point out that the objective of this Research Topic is in line with the United Nations Decade of Healthy Aging (2021–2030) Sustainable Development Goals, #SDG3, #SDG10, and #SDG11, which collectively seek to improve lives of older people, their families, and communities. Below, we selected several examples of manuscripts that address some of these Research Topic subjects and provide future directions.enAgeingAgingMuscle ArchitectureSarcopeniaSkeletal Muscle AtrophyArtículoCC BY 4.0 Attribution 4.0 International Deed10.3389/fphys.2023.1333577