Choi, Won IlaKamaly, NazilaaRiol-Blanco, LorenabLee, In-HyunaWu, JunaSwami, ArchanaaVilos, Cristiana, cYameen, BasitaYu, MikyungaShi, JinjunaTabas, Irad, e, fVon Andrian, Ulrich H.Jon, SangyonggFarokhzad, Omid C.2022-05-122022-05-122014-111530-6984https://repositorio.unab.cl/xmlui/handle/ria/22505Indexación: ScopusProtein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo. © 2014 American Chemical Society.enbiologicsNanoparticlessolvent-freetherapeutic proteinsthermospongeArtículoAtribución 4.0 Internacional (CC BY 4.0)10.1021/nl502994y