Baeza, EvelynCatalan, karenPeña-Cortes, HugoEspinoza, Luis2014-01-292016-05-242014-01-292016-05-242012Quím. Nova vol.35 no.3 São Paulo 20120100-4042DOI: http://dx.doi.org/10.1590/S0100-40422012000300015http://repositorio.unab.cl/xmlui/handle/ria/2348Indexación: Web of Science; ScieloNatural geranylhydroquinone 1 and geranyl-p-methoxyphenol 2 were prepared by Electrophilic Aromatic Substitution (EAS) reactions between geraniol and 1,4-hydroquinone or p-methoxyphenol respectively, using BF3∙Et2O as a catalyst. Furthermore, natural geranylquinone 3, geranyl-1,4-dimethoxyquinone 4 and the new geranyl-4-methoxyphenyl acetate 5 were obtained by chemical transformations of 1 and 2. The compounds were evaluated for their in vitro cytotoxicity activities against cultured human cancer cells of PC-3 human prostate cancer, MCF-7 and MDA-MB-231 breast carcinoma, and Dermal Human Fibroblasts DHF. IC50 values were in the µM range.englishNatural geranylhydroquinoneElectrophilic Aromatic Substitutionhydroquinone or p-methoxyphenoSYNTHESISCytotoxic activityArtículo