Control systems and coordination protocols of the secretory pathway
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Archivos
Fecha
2014-10
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
Faculty of 1000 Ltd
Nombre de Curso
Licencia CC
Atribution 4.0 International (CC BY 4.0)
Licencia CC
https://creativecommons.org/licenses/by/4.0/deed.es
Resumen
Like other cellular modules, the secretory pathway and the Golgi complex are likely to be supervised by
control systems that support homeostasis and optimal functionality under all conditions, including
external and internal perturbations. Moreover, the secretory apparatus must be functionally connected
with other cellular modules, such as energy metabolism and protein degradation, via specific rules of
interaction, or “coordination protocols”. These regulatory devices are of fundamental importance for
optimal function; however, they are generally “hidden” at steady state. The molecular components and
the architecture of the control systems and coordination protocols of the secretory pathway are
beginning to emerge through studies based on the use of controlled transport-specific perturbations
aimed specifically at the detection and analysis of these internal regulatory devices.
Notas
Indexación: Scopus.
Palabras clave
CAMP, Cyclic Adenosine Monophosphate, COPI, Coat Protein Complex I, ER, Endoplasmic Reticulum, GPCR, G Protein-Coupled Receptor, KDELR, KDEL Receptor, Protein Kinase A.
Citación
F1000Prime Reports. Volume 6. 1 October 2014. Article number 88
DOI
DOI: 10.12703/P6-88