Synthesis and conformational analysis of leptocarpin derivatives. Influence of modification of the oxirane ringon leptocarpin's cytotoxic activity.
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Fecha
2006
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
2014 Sociedad Chilena de Química
Nombre de Curso
Licencia CC
Licencia CC
Resumen
ABSTRACT
The reaction in acidconditions of Leptocarpin 1, a compound with antitumor activity, formed two new isomeric products, 8b-angeloyl-1b,3b-dihydroxy-4,10-dimethyl,-D11(13) methylen-4Z,9Z-dieneheliangol-6,12-olide 2 and 8b-angeloyl-1b,3b-dihydroxy-4-methyl-D11(13),D11(14)-dimethylen-4Z-eneheliangol-6,12-olide 3, whose structures reported in this study were established by spectroscopy (1H-NMR, 13C-NMR, MS and IR) and confirmedthrough ROESY experiments and theoretical studies by molecular mechanics. The in vitro cytotoxicity of these isomeric compounds was less active than leptocarpin, showing the importance of the oxirane ring in the biological activity. Cytotoxic activity was measured in six cancer cell lines.
Keywords: Conformational analysis; Heliangolide; Sesquiterpene lactones; Cytotoxicity.
Notas
Indexación: Scielo
Palabras clave
Conformational analysis; Heliangolide; Sesquiterpene lactones; Cytotoxicity.
Citación
Journal of the Chilean Chemical Society. Vol. 51. N° 4, 2006.