Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases
Archivos
Fecha
2016-07
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
FRONTIERS MEDIA SA
Nombre de Curso
Licencia CC
Licencia CC
Resumen
Under physiological conditions, astroglial hemichannels and pannexons allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory. However, recent evidence suggests that under pathological conditions, they may be central in the development of various neurodegenerative diseases. Here we review current literature on the role of astroglial hemichannels and pannexons in memory, stress and the development of neurodegenerative diseases, and propose that they are not only crucial for normal brain function, including memory, but also a potential target for the treatment of neurodegenerative diseases
Notas
Indexación: Web of Science
Palabras clave
Connexin hemichannels, Cx hemichannels, Connexin 43, Pannexin, Astrocytes, Memory
Citación
Front. Integr. Neurosci., 20 July 2016