Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin
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Fecha
2017-06
Profesor/a Guía
Facultad/escuela
Idioma
en
Título de la revista
ISSN de la revista
Título del volumen
Editor
MDPI
Nombre de Curso
Licencia CC
Licencia CC
https://creativecommons.org/licenses/by/4.0/
Resumen
An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.
Notas
Indexación: Web of Science; Scopus.
Palabras clave
Anti-oomycete activity, Isocordoin, Oxyalkyl derivates, Saprolegnia sp.
Citación
Molecules. Volume 22, Issue 6, June 2017, Article number 968