• Login
    View Item 
    •   DSpace Home
    • INVESTIGACIÓN ACADÉMICA
    • Facultad de Ciencias Exactas
    • FCE - Artículos de Revista
    • View Item
    •   DSpace Home
    • INVESTIGACIÓN ACADÉMICA
    • Facultad de Ciencias Exactas
    • FCE - Artículos de Revista
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Encapsulation of gold nanostructures and oil-in-water nanocarriers in microgels with biomedical potential

    Thumbnail
    View/Open
    TEXTO COMPLETO EN INGLES (757.4Kb)
    Date
    2018
    Author
    Inostroza-Riquelme, M.
    Vivanco, A.
    Lara, P.
    Guerrero, S.
    Salas-Huenuleo, E.
    Chamorro, A.
    Leyton, L.
    Bolaños, K.
    Araya, E.
    Quest, A.F.G.
    Kogan, M.J.
    Oyarzun-Ampuero, F.
    Metadata
    Show full item record
    Abstract
    Here we report the incorporation of gold nanostructures (nanospheres or nanorods, functionalized with carboxylate-end PEG) and curcumin oil-in-water (O/W) nanoemulsions (CurNem) into alginate microgels using the dripping technique. While gold nanostructures are promising nanomaterials for photothermal therapy applications, CurNem possess important pharmacological activities as reported here. In this sense, we evaluated the effect of CurNem on cell viability of both cancerous and non-cancerous cell lines (AGS and HEK293T, respectively), demonstrating preferential toxicity in cancer cells and safety for the non-cancerous cells. After incorporating gold nanostructures and CurNem together into the microgels, microstructures with diameters of 220 and 540 µm were obtained. When stimulating microgels with a laser, the plasmon effect promoted a significant rise in the temperature of the medium; the temperature increase was higher for those containing gold nanorods (11–12 ◦ C) than nanospheres (1–2 ◦ C). Interestingly, the incorporation of both nanosystems in the microgels maintains the photothermal properties of the gold nanostructures unmodified and retains with high efficiency the curcumin nanocarriers. We conclude that these results will be of interest to design hydrogel formulations with therapeutic applications. © 2018 by the authors.
    URI
    http://repositorio.unab.cl/xmlui/handle/ria/8958
    Collections
    • FCE - Artículos de Revista

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Documentos Trabajos de TitulaciónProcedimientos de publicaciónDerecho de autorGuía para Trabajos de Titulación pre y post gradoFormulario de AutorizaciónLogo Institucional

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    LoginRegister

    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV