Soybean Meal Induces Intestinal Inflammation in Zebrafish Larvae

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dc.contributor.authorHedrera, M.
dc.contributor.authorGaldames, J.
dc.contributor.authorJimenez-Reyes, M.
dc.contributor.authorReyes, A.
dc.contributor.authorAvendaño-Herrera, R.
dc.contributor.authorRomero, J.
dc.contributor.authorFeijóo, C.
dc.date.accessioned2023-04-24T17:07:54Z
dc.date.available2023-04-24T17:07:54Z
dc.date.issued2013-07
dc.descriptionIndexación: Scopus.
dc.description.abstractThe necessary replacement of fish meal with other protein source in diets of commercially important fish has prompted the study of the effect of the inclusion of different vegetable proteins sources on growth performance and on the gastro-intestinal tract. Currently, soybean meal is the primary protein source as a fish meal replacement because of its low price and high availability. Likewise, it is been documented that the ingestion of soybean meal by several fish species, such as salmonids and carp, triggers a type of intestinal inflammation called enteritis. In this paper, we analyzed the effects of the ingestion of soybean meal and two of its components, soy protein and soy saponin, on zebrafish to establish the basis for using zebrafish larvae as a model for fish nutrition. We took advantage of the existence of different transgenic lines, which allowed us to perform in vivo analysis. Our results indicated that larvae that were feed with soybean meal developed a clear intestinal inflammation as early as two day after beginning the diet. Moreover, we determined that is not the soy protein present in the diet but the soy saponin that is primarily responsible for triggering the immune response. These findings support the use of zebrafish screening assays to identify novel ingredients that would to improved current fish diets or would formulate new ones.es
dc.description.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0069983
dc.identifier.citationPLoS ONE, Volume 8, Issue 723, July 2013, Article number e69983es
dc.identifier.doi10.1371/journal.pone.0069983
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/48873
dc.language.isoenes
dc.publisherPublic Library of Sciencees
dc.rights.licenseAttribution 2.0 Generic (CC BY 2.0)
dc.rights.urihttps://journals.plos.org/plosone/s/journal-information#loc-open-access
dc.subjectFish Meales
dc.subjectDietes
dc.subjectHepatosomatic Indexes
dc.titleSoybean Meal Induces Intestinal Inflammation in Zebrafish Larvaees
dc.typeArtículoes
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