Examinando por Autor "Bassini, Liane N."

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    Comparative genomic analysis of three salmonid species identifies functional candidate genes involved in resistance to the intracellular bacterium Piscirickettsia salmonis
    (Frontiers in Genetics, 2019) Yáñez, José M.; Yoshida, Grazyella M.; Parra, Angel; Correa, Katharina; Barria, Agustin; Bassini, Liane N.; Christensen, Kris; Lopez Dinamarca, Maria E.; Carvalheiro, Roberto; Lhorente, Jean P.; Pulgar, Rodrigo E.
    We present two catalogs of radio-loud candidate blazars whose Wide-Field Infrared Survey Explorer (WISE) midinfrared colors are selected to be consistent with the colors of confirmed γ-ray-emitting blazars. The first catalog is the improved and expanded release of the WISE Blazar-like Radio-Loud Sources (WIBRaLS) catalog presented by D’Abrusco et al. It includes sources detected in all four WISE filters, spatially cross-matched with radio sources in one of three radio surveys and radio-loud based on their q22 spectral parameter. WIBRaLS2 includes 9541 sources classified as BL Lacs, flat-spectrum radio quasars, or mixed candidates based on their WISE colors. The second catalog, called KDEBLLACS, based on a new selection technique, contains 5579 candidate BL Lacs extracted from the population of WISE sources detected in the first three WISE passbands ([3.4], [4.6], and [12]) only, whose mid-infrared colors are similar to those of confirmed, γ-ray BL Lacs. Members of KDBLLACS are also required to have a radio counterpart and be radio-loud based on the parameter q12, defined similarly to the q22 used for the WIBRaLS2. We describe the properties of these catalogs and compare them with the largest samples of confirmed and candidate blazars in the literature. We cross-match the two new catalogs with the most recent catalogs of γ-ray sources detected by the Fermi Large Area Telescope. Since spectroscopic observations of candidate blazars from the first WIBRaLS catalog within the uncertainty regions of γ-ray unassociated sources confirmed that ∼90% of these candidates are blazars, we anticipate that these new catalogs will again play an important role in the identification of the γ-ray sky.
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    Genome-scale comparative analysis for host resistance against sea lice between Atlantic salmon and rainbow trout
    (Nature Research, 2021-12) Cáceres, Pablo; Barría, Agustín; Christensen, Kris A.; Bassini, Liane N.; Correa, Katharina; Garcia, Baltasar; Lhorente, Jean P.; Yáñez, José M.
    Sea lice (Caligus rogercresseyi) is an ectoparasite which causes major production losses in the salmon aquaculture industry worldwide. Atlantic salmon (Salmo salar) and rainbow trout (Oncorhynchus mykiss) are two of the most susceptible salmonid species to sea lice infestation. The objectives of this study were to: (1) identify genomic regions associated with resistance to Caligus rogercresseyi in Atlantic salmon and rainbow trout by performing single-step Genome-Wide Association studies (ssGWAS), and (2) identify candidate genes related to trait variation based on exploring orthologous genes within the associated regions across species. A total of 2626 Atlantic salmon and 2643 rainbow trout were challenged and genotyped with 50 K and 57 K SNP panels, respectively. We ran two independent ssGWAS for sea lice resistance on each species and identified 7 and 13 regions explaining more than 1% of the genetic variance for the trait, with the most important regions explaining 3% and 2.7% for Atlantic salmon and rainbow trout, respectively. We identified genes associated with immune response, cytoskeleton function, and cell migration when focusing on important genomic regions for each species. Moreover, we found 15 common orthogroups which were present in more than one associated genomic region, within- or between-species; however, only one orthogroup showed a clear potential biological relevance in the response against sea lice. For instance, dual-specificity protein phosphatase 10-like (dusp10) and dual-specificity protein phosphatase 8 (dusp8) were found in genomic regions associated with lice density in Atlantic salmon and rainbow trout, respectively. Dusp10 and dusp8 are modulators of the MAPK pathway and might be involved in the differences of the inflammation response between lice resistant and susceptible fish from both species. Our results provide further knowledge on candidate genes related to sea lice resistance and may help establish better control for sea lice in fish populations. © 2021, The Author(s).