Examinando por Autor "Catalán, Karen"

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    Synthesis and DPPH radical scavenging activity of prenylated phenol derivatives
    (MDPI, 2012-01) Osorio, Mauricio; Aravena, Jacqueline; Vergara, Alejandra; Taborga, Lautaro; Baeza, Evelyn; Catalán, Karen; González, Cesar; Carvajal, Marcela; Carrasco, Héctor; Espinoza, Luis
    The synthesis of twenty six prenylated phenols derivatives is reported. These compounds were obtained under mild conditions via Electrophilic Aromatic Substitution (EAS) coupling reactions between phenol derivatives containing electron-donor subtituents and 3-methyl-2-buten-1-ol using BF 3·OEt 2. Dialkylations were also produced with this method. The formation of a chroman ring by intramolecular cyclization between a sp 2 carbon from the prenyl group with the hydroxyl substituent in the ortho position occurred with some phenols. All the synthesized compounds were evaluated as antioxidants according to a DPPH radical scavenging activity assay. IC 50 values of five synthesized compounds indicated they were as good antioxidants as Trolox™. © 2012 by the authors.