Examinando por Autor "Costa, Jorge De Assis"

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    Effect of oral nutritional supplements with sucromalt and isomaltulose versus standard formula on glycaemic index, entero-insular axis peptides and subjective appetite in patients with type 2 diabetes: A randomised cross-over study
    (MDPI AG, 2019-07) Dávila, Lisse Angarita; Bermúdez, Valmore; Aparicio, Daniel; Céspedes, Virginia; Escobar, Ma Cristina; Durán-Agüero, Samuel; Cisternas, Silvana; Costa, Jorge De Assis; Rojas-Gómez, Diana; Reyna, Nadia; López-Miranda, Jose
    Oral diabetes-specific nutritional supplements (ONS-D) induce favourable postprandial responses in subjects with type 2 diabetes (DM2), but they have not been correlated yet with incretin release and subjective appetite (SA). This randomised, double-blind, cross-over study compared postprandial effects of ONS-D with isomaltulose and sucromalt versus standard formula (ET) on glycaemic index (GI), insulin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and SA in 16 individuals with DM2. After overnight fasting, subjects consumed a portion of supplements containing 25 g of carbohydrates or reference food. Blood samples were collected at baseline and at 30, 60, 90, 120, 150 and 180 min; and SA sensations were assessed by a visual analogue scale on separate days. Glycaemic index values were low for ONS-D and intermediate for ET (p < 0.001). The insulin area under the curve (AUC0–180 min) (p < 0.02) and GIP AUC (p < 0.02) were lower after ONS-D and higher GLP-1 AUC when compared with ET (p < 0.05). Subjective appetite AUC was greater after ET than ONS-D (p < 0.05). Interactions between hormones, hunger, fullness and GI were found, but not within the ratings of SA; isomaltulose and sucromalt may have influenced these factors. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.