Examinando por Autor "De La Fuente, J.R."

Mostrando 1 - 1 de 1
  • Miniatura
    Ítem
    Synthesis, physicochemical and photophysical characterization of 4-(1-Pyrenyl)-Butyl-α-d-mannopyranoside
    (Sociedade Brasileira de Química, 2016-02) Sandoval, C.; Arriagada, F.S.; De La Fuente, J.R.; Sanchez, S.A.; Morales, J.; Pizarro, N.; Nonell, S.; Gunther, G.
    Glycolipids are biomolecules composed of a lipid chain (lipophilic) and a monosaccharide or oligosaccharide as hydrophilic group. Their chemical structure and biological role make them undoubtedly good candidates for a large and continuously growing number of biotechnological applications. Mannose is a carbohydrate present on membrane glycolipids of a wide number of pathogenic microorganisms (bacteria, fungi, protozoa, and viruses) and specifically recognized by several lectins. We synthesized a mannose derivative linked through a short methylene chain to a pyrene moiety which behaves as a surfactant, able to aggregate, and retains the photophysical properties of pyrene: showing comparable absorption and emission spectra, having lower fluorescence quantum yield and the ability to form excimer, and finally the ability to produce O-2((1)Delta(g)) with high quantum yields. Thus, this novel molecule would open future applications for detection (fluorescence) or inactivation (singlet oxygen) of bacterial pathogens, viruses, tumor cells, or particular cells.