Examinando por Autor "Fernandez-Gamez, Beatriz"

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    Active gains in brain using exercise during aging (AGUEDA): protocol for a randomized controlled trial
    (Frontiers Media S.A., 2023) Solis-Urra, Patricio; Molina-Hidalgo, Cristina; García-Rivero, Yolanda; Costa-Rodriguez, Claudia; Mora-Gonzalez, Jose; Fernandez-Gamez, Beatriz; Olvera-Rojas, Marcos; Coca-Pulido, Andrea; Toval, Angel; Bellón, Darío; Sclafani, Alessandro; Martín-Fuentes, Isabel; Triviño-Ibañez, Eva María; de Teresa, Carlos; Huang, Haiqing; Grove, George; Hillman, Charles H.; Kramer, Arthur F.; Catena, Andrés; Ortega, Francisco B.; Gómez-Río, Manuel; Erickson, Kirk I.; Esteban-Cornejo, Irene
    Alzheimer’s disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent dementia risk. Physical exercise has been proposed as one of the leading non-pharmaceutical approaches to improve executive function and ameliorate cognitive decline. This single-site, two-arm, single-blinded, randomized controlled trial (RCT) will include 90 cognitively normal older adults, aged 65–80 years old. Participants will be randomized to a 24-week resistance exercise program (3 sessions/week, 60 min/session, n = 45), or a wait-list control group (n = 45) which will be asked to maintain their usual lifestyle. All study outcomes will be assessed at baseline and at 24-weeks after the exercise program, with a subset of selected outcomes assessed at 12-weeks. The primary outcome will be indicated by the change in an executive function composite score assessed with a comprehensive neuropsychological battery and the National Institutes of Health Toolbox Cognition Battery. Secondary outcomes will include changes in brain structure and function and amyloid deposition, other cognitive outcomes, and changes in molecular biomarkers assessed in blood, saliva, and fecal samples, physical function, muscular strength, body composition, mental health, and psychosocial parameters. We expect that the resistance exercise program will have positive effects on executive function and related brain structure and function, and will help to understand the molecular, structural, functional, and psychosocial mechanisms involved. Copyright © 2023 Solis-Urra, Molina-Hidalgo, García-Rivero, Costa-Rodriguez, Mora-Gonzalez, Fernandez-Gamez, Olvera-Rojas, Coca-Pulido, Toval, Bellón, Sclafani, Martín-Fuentes, Triviño-Ibañez, de Teresa, Huang, Grove, Hillman, Kramer, Catena, Ortega, Gómez-Río, Erickson and Esteban-Cornejo.
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    Ítem
    Resistance Exercise Program in Cognitively Normal Older Adults: CERT-Based Exercise Protocol of the AGUEDA Randomized Controlled Trial
    (Springer-Verlag Italia s.r.l., 2023-10) Fernandez-Gamez, Beatriz; Solis-Urra, P.; Olvera-Rojas, M.; Molina-Hidalgo, C.; Fernández-Ortega, J.; Lara, C.P.; Coca-Pulido, A.; Bellón, D.; Sclafani, A.; Mora-Gonzalez, J.; Toval, A.; Martín-Fuentes, I.
    Objectives: To provide a comprehensive CERT (Consensus on Exercise Reporting Template)-based description of the resistance exercise program implemented in the AGUEDA (Active Gains in brain Using Exercise During Aging) study, a randomized controlled trial investigating the effects of a 24-week supervised resistance exercise program on executive function and related brain structure and function in cognitively normal older adults. Design and Participants: 90 cognitively normal older adults aged 65 to 80 were randomized (1:1) to a: 1) resistance exercise group; or a 2) wait-list control group. Participants in the exercise group (n = 46) performed 180 min/week of resistance exercise (3 supervised sessions per week, 60 min/session) for 24 weeks. Intervention: The exercise program consisted of a combination of upper and lower limb exercises using elastic bands and the participant’s own body weight as the main resistance. The load and intensity were based on the resistance of the elastic bands (7 resistances), number of repetitions (individualized), motor complexity of exercises (3 levels), sets and rest (3 sets/60 sec rest), execution time (40–60 sec) and velocity (as fast as possible). Settings: The maximum prescribed-target intensity was 70–80% of the participants’ maximum rate of perceived exertion (7–8 RPE). Heart rate, sleep quality and feeling scale were recorded during all exercise sessions. Those in the wait-list control group (n = 44) were asked to maintain their usual lifestyle. The feasibility of AGUEDA project was evaluated by retention, adherence, adverse events and cost estimation on the exercise program. Results and Conclusions: This study details the exercise program of the AGUEDA trial, including well-described multi-language manuals and videos, which can be used by public health professionals, or general public who wish to implement a feasible and low-cost resistance exercise program. The AGUEDA exercise program seems to be feasible by the high retention (95.6%) and attendance rate (85.7%), very low serious adverse event (1%) and low economic cost (144.23 € /participant/24 weeks). We predict that a 24-week resistance exercise program will have positive effects on brain health in cognitively normal older adults. © 2023, The Author(s).