Examinando por Autor "Fuentes, DE"

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    The product of the qacC gene of Staphylococcus epidermidis CH mediates resistance to β-lactam antibiotics in Gram-positive and Gram-negative bacteria
    (Elsevier, 2005-05-01) Fuentes, DE; Navarro, CA; Tantaleán, JC; Araya, MA; Saavedra, CP; Pérez, JM; Calderón, IL; Youderian, PA; Mora, GC; Vásquez, CC
    We have characterized a natural isolate of Staphylococcus epidermidis resistant to heavy metals that carries a small 2391-bp plasmid, pSepCH, encoding the qacC gene. The S. epidermidis qacC gene confers resistance to a number of beta-lactam antibiotics and to ethidium bromide in its natural host and in Escherichia coli K12 and Salmonella enterica sv. Typhimurium. This is the first communication of a small multidrug resistance (SMR) pump involved in resistance to beta-lactam antibiotics. Experiments using tolC, ompW and ompD mutant strains of S. Typhimurium demonstrated that the beta-lactam antibiotic resistance conferred by this pump does not depend on these outer membrane proteins. (c) 2005 Elsevier SAS. All rights reserved.