Examinando por Autor "Izquierdo, Mikel"
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Ítem A Higher Skeletal Muscle Mass and Lower Adiposity Phenotype Is Associated with Better Cardiometabolic Control in Adults with Hip and Knee Osteoarthritis: Results from the Chilean National Health Survey 2016–2017(MDPI, 2023-09) Guede-Rojas, Francisco; Ibacache-Saavedra, Paulina; Leal, María Inés; Tuesta, Marcelo; Durán-Marín, Cristóbal; Carrasco-Marín, Fernanda; Cigarroa, Igor; Alvarez, Cristian; Izquierdo, Mikel; Delgado-Floody, PedroObjective: This study aimed to (1) characterize cardiometabolic factors in self-reported hip and knee osteoarthritis (OAD) across four body composition phenotypes defined by muscle mass and adiposity, and (2) associate risk factors with diabetes and hypertension (HTN). Methods: A cross-sectional analysis of the Chilean National Health Survey 2016–17 (n = 4996) stratified participants into four groups: low skeletal muscle mass/high waist circumference (Low-SMM/High-WC), low SMM/low WC (Low-SMM/Low-WC), high SMM/high WC (High-SMM/High-WC), and high SMM/low WC (reference group). Each group was further divided into subgroups with or without diagnosed hip or knee OAD. The main outcomes were fasting plasma glucose, systolic (SBP)/diastolic (DBP) blood pressure (continuous outcomes), and other secondary factors such as cardiovascular risk (CVR). Results: In the hip OAD subgroup, the Low-SMM/High-WC groups had significantly higher SBP versus the reference value (145 vs. 127 mmHg, p < 0.0001, diff +18 mmHg). In the knee OAD subgroup, the Low-SMM/High-WC groups had significantly higher SBP versus the reference value (141 vs. 134 mmHg, p < 0.0001, diff +7 mmHg). The SBP showed a significant interaction between the group and OAD diagnosis (p = 0.007 hip OAD; p < 0.0001 knee OAD). Conclusions: Hip and knee OAD associates with elevated SBP/DBP in older adults. OAD groups showed an OR above 2 for diabetes, 2.7 for HTN, 4.5 for metabolic syndrome, and over 2 for moderate-to-high cardiovascular risk. OAD interacts substantially with cardiometabolic factors, especially in low muscle mass/high adiposity phenotypes. Lifestyle optimization of physical activity and nutrition to preserve muscle mass and mitigate adiposity is essential for cardiometabolic health promotion in OAD patients. © 2023 by the authors.Ítem Anthropometric Characteristics, Handgrip Strength, and Upper Limb Asymmetries in Highly Trained Chilean Shot Put Para-Athletes(Universidad de la Frontera, 2023) Garcia-Carrillo, Exal; Yáñez-Sepúlveda, Rodrigo; Cortés-Roco, Guillermo; Ramirez-Campillo, Rodrigo; Izquierdo, MikelAnthropometric characteristics, including body size, shape, and composition, can have a significant impact on sports performance due to their influence on various physiological and biomechanical factors. However, limited research has been conducted on the anthropometric characteristics of highly trained throwing para-athletes. The purpose of this study was to describe the anthropometric characteristics, handgrip strength, and upper limb bilateral asymmetries of highly trained Chilean shot put para-throwers. Five male Chilean shot put para-athletes (average age of 38.8 ± 7.7 years) were assessed for their anthropometric characteristics, including skinfold thickness at six anatomical sites, girth at five sites, and bone breadth at two sites. Handgrip strength and bilateral asymmetries were also measured. The body mass and height of the athletes were found to be 90.5 ± 5.1 kg and 179.1 ± 8.9 cm, respectively. The athletes were found to have an endo-mesomorph somatotype (4.4-6.9-1.0) with high levels of fat mass (25.7 ± 2.8 %) and skeletal muscle mass (39.1 ± 3.7 %). The handgrip strength of the athletes was found to be 66.4 ± 6.7 kg with a bilateral asymmetry of 6.5 ± 6.2 %, with the dominant hand showing greater strength. The results indicate that the shot put para-athletes have a somatotype characterized by increased muscularity and body fat, along with a considerable stature. Although handgrip strength was found to be high, the athletes showed bilateral asymmetry, which requires further investigation to determine the cause and implications. © 2023, Universidad de la Frontera. All rights reserved.Ítem Cardiorespiratory optimal point as a submaximal evaluation tool in endurance athletes: An exploratory study(Frontiers Media S.A., 2023) Oyarzo-Aravena, Alexis; Arce-Alvarez, Alexis; Salazar-Ardiles, Camila; Ramirez-Campillo, Rodrigo; Alvarez, Cristian; Toledo, Camilo; Izquierdo, Mikel; Andrade, David C.Introduction: The cardiorespiratory optimal point (COP) represents the lowest minute ventilation to oxygen consumption ratio (VE/VO2) and can be estimated during a CPET at submaximal intensity when an exercise test until volitional fatigue is not always advisable (i.e., a conflict zone where you cannot be confident of the security because near-competition, off-season, among other). COP’s physiological components have not been wholly described yet. Therefore, this study seeks to identify the determinants of COP in highly trained athletes and its influence on maximum and sub-maximum variables during CPET through principal c omponent analysis (PCA) (explains the dataset’s variance). Methods: Female (n = 9; age, 17.4 ± 3.1 y; maximal VO2 [VO2max]), 46.2 ± 5.9 mL/kg/min) and male (n = 24; age, 19.7 ± 4.0 y; VO2max, 56.1 ± 7.6 mL/kg/min) athletes performed a CPET to determine the COP, ventilatory threshold 1 (VT1) and 2 (VT2), and VO2max. The PCA was used to determine the relationship between variables and COP, explaining their variance. Results: Our data revealed that females and males displayed different COP values. Indeed, males showed a significant diminished COP compared to the female group (22.6 ± 2.9 vs. 27.2 ±3.4 VE/VO2, respectively); nevertheless, COP was allocated before VT1 in both groups. Discussion: PC analysis revealed that the COP variance was mainly explained (75.6%) by PC1 (expired CO2 at VO2max) and PC2 (VE at VT2), possibly influencing cardiorespiratory efficiency at VO2max and VT2. Our data suggest that COP could be used as a submaximal index to monitor and assess cardiorespiratory system efficiency in endurance athletes. The COP could be particularly useful during the offseason and competitive periods and the return to the sports continuum. Copyright © 2023 Oyarzo-Aravena, Arce-Alvarez, Salazar-Ardiles, Ramirez-Campillo, Alvarez, Toledo, Izquierdo and Andrade.Ítem Dynamic circadian fluctuations of glycemia in patients with type 2 diabetes mellitus(BioMed Central Ltd, 2022-12) Vásquez Muñoz, Manuel; Arce Álvarez, Alexis; Álvarez, Cristian; Ramírez Campillo, Rodrigo; Crespo, Fernando A.; Arias, Dayana; Salazar Ardiles, Camila; Izquierdo, Mikel; Andrade, David C.Background: Diabetes mellitus (DM) has glucose variability that is of such relevance that the appearance of vascular complications in patients with DM has been attributed to hyperglycemic and dysglycemic events. It is known that T1D patients mainly have glycemic variability with a specific oscillatory pattern with specific circadian characteristics for each patient. However, it has not yet been determined whether an oscillation pattern represents the variability of glycemic in T2D. This is why our objective is to determine the characteristics of glycemic oscillations in T2D and generate a robust predictive model. Results: Showed that glycosylated hemoglobin, glycemia, and body mass index were all higher in patients with T2D than in controls (all p < 0.05). In addition, time in hyperglycemia and euglycemia was markedly higher and lower in the T2D group (p < 0.05), without significant differences for time in hypoglycemia. Standard deviation, coefficient of variation, and total power of glycemia were significantly higher in the T2D group than Control group (all p < 0.05). The oscillatory patterns were significantly different between groups (p = 0.032): the control group was mainly distributed at 2–3 and 6 days, whereas the T2D group showed a more homogeneous distribution across 2–3-to-6 days. Conclusions: The predictive model of glycemia showed that it is possible to accurately predict hyper- and hypoglycemia events. Thus, T2D patients exhibit specific oscillatory patterns of glycemic control, which are possible to predict. These findings may help to improve the treatment of DM by considering the individual oscillatory patterns of patients. © 2022, The Author(s).Ítem Effects of Therapies Involving Plyometric-Jump Training on Physical Fitness of Youth with Cerebral Palsy: A Systematic Review with Meta-Analysis(Multidisciplinary Digital Publishing Institute (MDPI), 2024-06) Garcia-Carrillo, Exal; Ramirez-Campillo, Rodrigo; Izquierdo, Mikel; Elnaggar, Ragab K.; Afonso, José; Peñailillo, Luis; Araneda, Rodrigo; Ebner-Karestinos, Daniela; Granacher, UrsThe aim of this systematic review was to assess the effects of plyometric-jump training (PJT) on the physical fitness of youth with cerebral palsy (CP) compared with controls (i.e., standard therapy). The PRISMA 2020 guidelines were followed. Eligibility was assessed using the PICOS approach. Literature searches were conducted using the PubMed, Web of Science, and SCOPUS databases. Methodological study quality was assessed using the PEDro scale. Data were meta-analyzed by applying a random-effects model to calculate Hedges’ g effect sizes (ES), along with 95% confidence intervals (95% CI). The impact of heterogeneity was assessed (I2 statistic), and the certainty of evidence was determined using the GRADE approach. Eight randomized-controlled studies with low-to-moderate methodological quality were included, involving male (n = 225) and female (n = 138) youth aged 9.5 to 14.6 years. PJT interventions lasted between 8 and 12 weeks with 2–4 weekly sessions. Compared with controls, PJT improved the muscle strength (ES = 0.66 [moderate], 95% CI = 0.36–0.96, p < 0.001, I2 = 5.4%), static (ES = 0.69 [moderate], 95% CI= 0.33–1.04, p < 0.001, I2 = 0.0%) and dynamic balance (ES = 0.85 [moderate], 95% CI = 0.12–1.58, p = 0.023, I2 = 81.6%) of youth with CP. Therefore, PJT improves muscle strength and static and dynamic balance in youth with CP compared with controls. However, more high-quality randomized-controlled trials with larger sample sizes are needed to provide a more definitive recommendation regarding the use and safety of PJT to improve measures of physical fitness.Ítem Effects of Upper-Body Plyometric Training on Physical Fitness in Healthy Youth and Young Adult Participants: A Systematic Review with Meta-Analysis(Springer Science and Business Media Deutschland GmbH, 2023-12) Garcia-Carrillo, Exal; Ramirez-Campillo, Rodrigo; Thapa, Rohit K.; Afonso, José; Granacher, Urs; Izquierdo, MikelBackground: Upper-body plyometric training (UBPT) is a commonly used training method, yet its effects on physical fitness are inconsistent and there is a lack of comprehensive reviews on the topic. Objective: To examine the effects of UBPT on physical fitness in healthy youth and young adult participants compared to active, specific-active, and passive controls. Methods: This systematic review followed PRISMA 2020 guidelines and utilized the PICOS framework. PubMed, WOS, and SCOPUS were searched. Studies were assessed for eligibility using the PICOS framework. The effects of UBPT on upper-body physical fitness were assessed, including maximal strength, medicine ball throw performance, sport-specific throwing performance, and upper limb muscle volume. The risk of bias was evaluated using the PEDro scale. Means and standard deviations were used to calculate effect sizes, and the I 2 statistic was used to assess heterogeneity. Publication bias was assessed using the extended Egger's test. Certainty of evidence was rated using the GRADE scale. Additional analyses included sensitivity analyses and adverse effects. Results: Thirty-five studies were included in the systematic review and 30 studies in meta-analyses, involving 1412 male and female participants from various sport-fitness backgrounds. Training duration ranged from 4 to 16 weeks. Compared to controls, UBPT improved maximal strength (small ES = 0.39 95% CI = 0.15–0.63, p = 0.002, I 2 = 29.7%), medicine ball throw performance (moderate ES = 0.64, 95% CI = 0.43–0.85, p < 0.001, I 2 = 46.3%), sport-specific throwing performance (small ES = 0.55, 95% CI = 0.25–0.86, p < 0.001, I 2 = 36.8%), and upper limbs muscle volume (moderate ES = 0.64, 95% CI = 0.20–1.08, p = 0.005, I 2 = 0.0%). The GRADE analyses provided low or very low certainty for the recommendation of UBPT for improving physical fitness in healthy participants. One study reported one participant with an injury due to UBPT. The other 34 included studies provided no report measure for adverse effects linked to UBPT. Conclusions: UBPT interventions may enhance physical fitness in healthy youth and young adult individuals compared to control conditions. However, the certainty of evidence for these recommendations is low or very low. Further research is needed to establish the optimal dose of UBPT and to determine its effect on female participants and its transfer to other upper-body dominated sports.Ítem Handgrip strength, cardiometabolic risk and body composition in youth with type 1 diabetes: the Diactive-1 Cohort Study(BMJ Publishing Group, 0024-12) Huerta-Uribe, Nidia; Hormazábal-Aguayo, Ignacio; Muñoz-Pardeza, Jacinto; Chueca-Guindulain, María J; Berrade-Zubiri, Sara; Sesma, Carlos Andrés; Sánchez, Elisabet Burillo; Ezzatvar, Yasmin; Yáñez-Sepúlveda, Rodrigo; Izquierdo, Mikel; García-Hermoso, AntonioObjective This study aimed to explore the association between handgrip strength, cardiometabolic risk (CMR) and body composition in youth with type 1 diabetes. Methods For this prospective cohort study, muscular fitness was assessed via handgrip test and relativised by weight, and body composition, evaluated through dual-energy X-ray absorptiometry in type 1 diabetes patients aged 6-18 years. CMR score included z-scores for total body fat, blood pressure, glycated haemoglobin (HbA1c), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglyceride-glucose index. Results Eighty-three patients were analysed at baseline and 1-year follow-up (44.6% females, mean age 12.77 years). Individuals with high handgrip strength tended to have lower CMR and body fat compared with those with low handgrip strength. Over a year, individuals with high handgrip strength showed reduced HbA1c, CMR and subcutaneous fat. Consistently meeting high handgrip strength criteria resulted in reductions in HbA1c levels, CMR score and subcutaneous adipose tissue compared with those who never complied or lost compliance during follow-up. Additionally, subjects classified with high handgrip strength both at baseline and follow-up had a lower likelihood of being classified with high CMR (OR=0.241, 95% CI 0.121 to 0.947, p=0.044). Conclusions High handgrip strength was associated with significant cardiometabolic and body composition benefits in youth with type 1 diabetes. This tool could be considered of potential clinical value for incorporating assessments like handgrip tests to monitor and address cardiometabolic health. © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ.Ítem Handgrip strength, cardiometabolic risk and body composition in youth with type 1 diabetes: the Diactive-1 Cohort Study(BMJ Publishing Group, 2024-12-04) Huerta-Uribe, Nidia; Hormazábal-Aguayo, Ignacio; Muñoz-Pardeza, Jacinto; Chueca-Guindulain, María J; Berrade-Zubiri, Sara; Sesma, Carlos Andrés; Sánchez, Elisabet Burillo; Ezzatvar, Yasmin; Yáñez-Sepúlveda, Rodrigo; Izquierdo, Mikel; García-Hermoso, AntonioObjective This study aimed to explore the association between handgrip strength, cardiometabolic risk (CMR) and body composition in youth with type 1 diabetes. Methods For this prospective cohort study, muscular fitness was assessed via handgrip test and relativised by weight, and body composition, evaluated through dual-energy X-ray absorptiometry in type 1 diabetes patients aged 6-18 years. CMR score included z-scores for total body fat, blood pressure, glycated haemoglobin (HbA1c), low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglyceride-glucose index. Results Eighty-three patients were analysed at baseline and 1-year follow-up (44.6% females, mean age 12.77 years). Individuals with high handgrip strength tended to have lower CMR and body fat compared with those with low handgrip strength. Over a year, individuals with high handgrip strength showed reduced HbA1c, CMR and subcutaneous fat. Consistently meeting high handgrip strength criteria resulted in reductions in HbA1c levels, CMR score and subcutaneous adipose tissue compared with those who never complied or lost compliance during follow-up. Additionally, subjects classified with high handgrip strength both at baseline and follow-up had a lower likelihood of being classified with high CMR (OR=0.241, 95% CI 0.121 to 0.947, p=0.044). Conclusions High handgrip strength was associated with significant cardiometabolic and body composition benefits in youth with type 1 diabetes. This tool could be considered of potential clinical value for incorporating assessments like handgrip tests to monitor and address cardiometabolic health.Ítem Heart Rate from Progressive Volitional Cycling Test Is Associated with Endothelial Dysfunction Outcomes in Hypertensive Chilean Adults(2023-03) Alvarez, Cristian; Tuesta, Marcelo; Reyes, Álvaro; Guede-Rojas, Francisco; Peñailillo, Luis; Cigarroa, Igor; Vásquez-Gómez, Jaime; Cano-Montoya, Johnattan; Durán-Marín, Cristóbal; Rojas-Paz, Oscar; Márquez, Héctor; Izquierdo, Mikel; Delgado-Floody, PedroBackground: A progressive volitional cycling test is useful in determining exercise prescription in populations with cardiovascular and metabolic diseases. However, little is known about the association between heart rate during this test and endothelial dysfunction (EDys) parameters in hypertensive (HTN) patients. Objective: To investigate the association between EDys markers (flow-mediated dilation [FMD], pulse wave velocity of the brachial artery [PWVba], and carotid-intima media thickness [cIMT]) and heart rate during a cycling test in HTN adults. A secondary aim was to characterize cardiovascular, anthropometric, and body composition outcomes in this population. Methods: This was a descriptive clinical study in which adults (men and women) were assigned to one of three groups: HTN, elevated blood pressure (Ele), or a normotensive control group (CG), and completed a progressive cycling test. The primary outcomes were FMD, PWVba, cIMT, and heart rate (HR) at 25–50 watts (HR25–50), 50–100 watts (HR50–100), and 75–150 watts (HR75–150) of the Astrand test. Secondary outcomes included body mass index (BMI), waist circumference, body fat percentage (BF%), skeletal muscle mass (SMM), resting metabolic rate (RMR), and estimated body age, as measured by a bio-impedance digital scale. Results: Analyses of the associations between FMD, PWV, and HR25–50, HR50–100, and HR75–150 watts revealed no significant association in the HTN, Ele, and CG groups. However, a significant association was found between cIMT and HR75–150 watts in the HTN group (R2 47.1, β −0.650, p = 0.038). There was also a significant trend (p = 0.047) towards increasing PWVba in the CG, Ele, and HTN groups. Conclusion: Heart rate during a progressive cycling test is associated with the EDys parameters cIMT in HTN patients, with particularly strong predictive capacity for vascular parameters in the second and third stages of the Astrand exercise test compared to normotensive control. © 2023 by the authors.Ítem Hypertensive patients show higher heart rate response during incremental exercise and elevated arterial age estimation than normotensive adult peers: VASCU-HEALTH PROJECT(Federación Española de Docentes de Educación Física, 2023) Alvarez, Cristian; Campos-Jara, Christian; Gomes Ciolac, Emmanuel; Vega Guimaraes, Guilherme; Andrade-Mayorga, Omar; Cano-Montoya, Johnattan; Andrade, David C.; Delgado-Floody, Pedro; Alonso-Martínez, Alicia; Izquierdo, Mikel; Cigarroa, IgorThere is limited information regarding heart rate (HR) response from predictive formulae and actual exercise tests between arterial hypertension (HTN) and normotensive adults, as well as about vascular similarities or differences between samples of different blood pressure control. This study aimed 1) to describe and compare the HR during exercise between HTN and normotensive adults and 2) to describe the endothelial function and related vascular parameters in both groups. A descriptive clinical study was conducted with 64 adults (men and women) who were divided into three groups: arterial hypertension (HTN n=26), elevated blood pressure (Ele n=16), or normotensive control (CG n=22). The participants underwent an incremental cycling exercise test of 5 stages, where HR (primary outcome) was measured, and secondary vascular outcomes (percentile classification of the pulse wave velocity (%ILEPWVba), maximum carotid intima-media thickness (cIMTmax), and arterial age among others were measured. In stage 2 of the test (50-100 watts), the HTN group showed significantly higher HR vs. CG (+14 beats/min; p<0.05) and vs. Ele group (+15 beats/min; p<0.05), and in stage 5 (125-250 watts), HTN group showed higher HR vs. CG (+22 beats/min; p<0.05). HTN group showed a higher arterial stiffness by %ILEPWVba classification and arterial age estimation than the CG group. In conclusion, HTN patients reported a higher HR response only in two out of five (monitored) stages of the Astrand cycling exercise test than normotensive peers. Moreover, all groups showed a higher HRpredicted than real HRpeak obtained from the exercise test. These results are displayed with more altered vascular parameters in the HTN group. © Copyright: Federación Española de Asociaciones de Docentes de Educación Física (FEADEF)Ítem Hypoxic peripheral chemoreflex stimulation-dependent cardiorespiratory coupling is decreased in swimmer athletes(American Physiological Society, 2024-01) Andrade, David C.; Arce-Álvarez, Alexis; Salazar-Ardiles, Camila; Toledo, Camilo; Guerrero-Henriquez, Juan; Alvarez, Cristian; Vasquez-Muñoz, Manuel; Izquierdo, Mikel; Millet, Gregoire P.Swimmer athletes showed a decreased ventilatory response and reduced sympathetic activation during peripheral hypoxic chemoreflex stimulation. Based on these observations, we hypothesized that swimmers develop a diminished cardiorespiratory coupling due to their decreased hypoxic peripheral response. To resolve this hypothesis, we conducted a study using coherence time-varying analysis to assess the cardiorespiratory coupling in swimmer athletes. We recruited 12 trained swimmers and 12 control subjects for our research. We employed wavelet time-varying spectral coherence analysis to examine the relationship between the respiratory frequency (Rf) and the heart rate (HR) time series during normoxia and acute chemoreflex activation induced by five consecutive inhalations of 100% N2. Comparing swimmers to control subjects, we observed a significant reduction in the hypoxic ventilatory responses to N2 in swimmers (0.012 ± 0.001 vs. 0.015 ± 0.001 ΔVE/ΔVO2, and 0.365 ± 0.266 vs. 1.430 ± 0.961 ΔVE/ΔVCO2/ΔSpO2, both p < 0.001, swimmers vs. control, respectively). Furthermore, the coherence at the LF cutoff during hypoxia was significantly lower in swimmers compared to control subjects (20.118 ± 3.502 vs. 24.935 ± 3.832 area under curve [AUC], p < 0.012, respectively). Our findings strongly indicate that due to their diminished chemoreflex control, swimmers exhibited a substantial decrease in cardiorespiratory coupling during hypoxic stimulation. © 2024 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.Ítem Interindividual Variability Response to Resistance and High-Intensity Interval Training on Blood Pressure Reduction in Hypertensive Older Adults(Multidisciplinary Digital Publishing Institute (MDPI), 2025-01) Cano-Montoya, Johnattan; Hurtado, Nicolas; Hurtado N.; Núñez Vergara, Carolina; Báez Vargas, Sebastián; Rojas-Vargas, Marcela; Martínez-Huenchullán, Sergio; Izquierdo, MikelThis study evaluated the effects of resistance training (RT) and high-intensity interval training (HIIT) on systolic (SBP) and diastolic blood pressure (DBP) in hypertensive older adults undergoing pharmacological therapy over four and eight weeks. We compared the efficacy of RT and HIIT in reducing non-responders (NRs) between weeks 4 and 8 and analyzed time-course adaptations in NRs and responders (Rs). Methods: Thirty-nine participants were randomized into RT-G (n = 13), HIIT-G (n = 13), or control (CG, n = 13) groups. RT utilized elastic bands, and HIIT involved cycle ergometers, with three weekly 30 min sessions for 8 weeks. SBP and DBP were measured before intervention and at weeks 4 and 8, respectively. Individual responses were classified as NRs or Rs using the Hopkins method (SDIR = √[SDExp2–SDCon2]). Time-course adaptations were evaluated. Results: Both the RT-G and HIIT-G reduced SBP at 8 weeks (RT-G: −13 mmHg; [ES: 1.12]; HIIT-G: −12 mmHg [ES: 0.8]; both p < 0.05). The proportion of NRs for SBP decreased from 46% to 38% in RT-G and 69% to 46% in HIIT-G. Rs showed a peak SBP reduction at 4 weeks (−14.7 and −25.5 mmHg), stabilizing by week 8 (−22.8 and −19.6 mmHg) in RT-G and HIIT-G, respectively. Conclusion: Eight weeks of RT and HIIT effectively reduced SBP and NR prevalence, with time-course adaptations favoring Rs.Ítem Regional fat changes induced by localized muscle endurance resistance training(Lippincott, Williams & Wilkins, 2013-08) Ramírez-Campillo, Rodrigo; Andrade, David C.; Campos-Jara, Christian; Henríquez-Olguín, Carlos; Alvarez-Lepín, Cristian; Izquierdo, MikelThe purpose of this study was to examine the effects of a localized muscle endurance resistance training program on total body and regional tissue composition. Seven men and 4 women (aged 236 1 years) were trained with their nondominant leg during 12 weeks, 3 sessions per week. Each session consisted of 1 set of 960-1,200 repetitions (leg press exercise), at 10-30% 1 repetition maximum. Before and after training, body mass, bone mass, bone mineral density (BMD), lean mass, fat mass, and fat percentage were determined by dual-emission x-ray absorptiometry. Energy intakes were registered using a food recall questionnaire. At the wholebody level, body mass, bone mass, BMD, lean mass, or body fat percentage were not significantly changed. However, body fat mass significantly decreased by 5.1% (preexercise: 13.5 6 6.3 kg; postexercise: 12.8 ± 5.4 kg, p < 0.05). No significant changes in bone mass, lean mass, fat mass, or fat percentage were observed in both the control and trained leg. A significant (p < 0.05) decrease in fat mass was observed in the upper extremities and trunk (10.2 and 6.9%, respectively, p < 0.05). The reduction of fat mass in the upper extremities and trunk was significantly greater (p < 0.05) than the fat mass change observed in the trained leg but not in the control leg. No significant changes were observed in energy intake pre- and postexercise intervention (2,646 ± 444 kcal$d21 and 2,677 ± 617 kcal$d21, respectively). In conclusion, the training program was effective in reducing fat mass, but this reduction was not achieved in the trained body segment. The present results expand the limited knowledge available about the plastic heterogeneity of regional body tissues when a localized resistance training program is applied. © 2013 National Strength and Conditioning Association.