Examinando por Autor "Lamazares, Emilio"

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    Kinetic study of removal heavy metal from aqueous solution using the synthetic aluminum silicate
    (Nature Research, 2020-12) Treto-Suárez, Manuel Alejandro; Prieto-García, Julio Omar; Mollineda-Trujillo, Ángel; Lamazares, Emilio; Hidalgo-Rosa, Yoan; Mena-Ulecia, Karel
    One of the problems that most affect humanity today is the wastewater discharge into different water bodies. It was estimated that more than 7 million tons of wastewater are generated worldwide and are discharged into rivers, lakes, and reservoirs. Among the most dangerous wastewaters are those from inorganic chemistry research laboratories, mainly due to heavy metals. These problems have become a highly relevant topic, and numerous researchers have tried to design wastewater treatment systems that will deal more efficiently with heavy metals elimination. In this work, the synthesis, characterization, and evaluation of hydrated aluminium silicate were performed as alternative wastewater treatment from chemistry research and teaching laboratories. The compound obtained was Al_2O_33SiO_2H_2O, which was characterized by the determination of its physicochemical properties. These revealed a low density, very porous material, with low crystallinity, strong chemical resistance, a large surface area, and a high apparent ionic exchange capacity. Absorption kinetics studies of heavy metals in aqueous solutions, through more widespread models, have demonstrated that Al_2O_33SiO_2H_2O has excellent properties as absorbents of this material. The amorphous hydrated aluminium silicate achieves a decrease in the concentration of all the metal ions studied, reducing them to discharge levels permissible.
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    New insight into the biological activity of Salmo salar NK-lysin antimicrobial peptides
    (Frontiers Media SA, 2024-01) Ortega, Leonardo; Carrera, Crisleri; Muñoz-Flores, Carolina; Salazar, Santiago; Villegas, Milton F.; Starck, María F.; Valenzuela, Ariel; Agurto, Niza; Montesino, Raquel; Astuya, Allisson; Parra, Natalie; Pérez, Ercilia T.; Santibáñez, Natacha; Romero, Alex; Ruíz, Pamela; Lamazares, Emilio; Reyes, Fátima; Sánchez, Oliberto; Toledo, Jorge R.; Acosta, Jannel
    NK-lysin is a potent antimicrobial peptide (AMP) with antimicrobial activity against bacteria, fungi, viruses, and parasites. NK-lysin is a type of granulysin, a member of the saposin-like proteins family first isolated from a pig’s small intestine. In previous work, for the first time, we identified four variants of nk-lysin from Atlantic salmon (Salmo salar) using EST sequences. In the present study, we reported and characterized two additional transcripts of NK-lysin from S. salar. Besides, we evaluated the tissue distribution of three NK-lysins from S. salar and assessed the antimicrobial, hemolytic, and immunomodulatory activities and signaling pathways of three NK-lysin-derived peptides. The synthetic peptides displayed antimicrobial activity against Piscirickettsia salmonis (LF-89) and Flavobacterium psychrophilum. These peptides induced the expression of immune genes related to innate and adaptive immune responses in vitro and in vivo. The immunomodulatory activity of the peptides involves the mitogen-activated protein kinases-mediated signaling pathway, including p38, extracellular signal-regulated kinase 1/2, and/or c-Jun N-terminal kinases. Besides, the peptides modulated the immune response induced by pathogen-associated molecular patterns (PAMPs). Our findings show that NK-lysin could be a highly effective immunostimulant or vaccine adjuvant for use in fish aquaculture.