Examinando por Autor "Lara, Felipe"

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    Changes in the gut microbiome and colic in horses: Are they causes or consequences?
    (Faculty of Veterinary Medicine, University of Tripoli, 2022) Lara, Felipe; Castro, Rodrigo; Thomson, Pamela
    The gut microbiome is a compound for millions of microorganisms that coexist in an organized way and contribute to the fermentation of different types of indigestible fibers by the small intestine. Some techniques, such as the massive sequencing of the 16S ribosomal RNA gene, have made it possible to obtain information about the abundance and functionality of the microorganisms that compose the equine gut microbiome and the interaction with their environment. Recent studies have identified the change in the composition of the intestinal microbiome during and after a colic episode, although is not clear if it is a cause or a consequence. The objective of this review was to elucidate whether there is a direct relationship between the changes that occur in the gut microbiome and colic in the equine. A systematized search in Embase, Web of Science, and PubMed was realized. Although there is good evidence that horses with colic have a change in their gut microbiome, it is not fully understood whether these changes are causes or effects. It is necessary to delve into this topic, considering studying larger population sizes. In addition, it would be of great value to previously know the normal intestinal microbiome of a group of healthy horses, which in the future could develop an episode of colic, to compare the before and after in the same individual. © 2022, Faculty of Veterinary Medicine, University of Tripoli. All rights reserved.
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    Preliminary Functional Analysis of the Gut Microbiome in Colic Horses
    (Multidisciplinary Digital Publishing Institute (MDPI), 2024-11) Thomson, Pamela; Garrido, Daniel; Santibáñez, Rodrigo; Lara, Felipe
    Colic in horses is a common condition that can affect different organs of the abdominal cavity. In recent years, attempts have been made to associate this pathology with changes that occur in the intestinal microbiome. Through a case–control study, we analyzed the intestinal microbiome of a group of healthy horses and another with colic by massive sequencing of 16S rRNA to observe the differences in the bacterial composition and functionality of these groups. The intestinal microbiomes of both groups are dominated by the phyla Firmicuteota, Bacteroidota, and Pseudomonadota. The abundance of Firmicuteota was negatively correlated with Pseudomonadota and Actinobacteriota in horses with colic. The microbiome of equine colic was predicted to be enriched with aerobic respiration pathways and fatty acid and amino acid degradation, observations that indicate discrete but important differences in the intestinal microbiome of horses with colic, which correlate with a more pro-inflammatory microbial community.