Examinando por Autor "Martínez, José"

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    Pharmacotherapy and clinical outcomes of hospitalized COVID-19 patients in Chile during the first wave of pandemic
    (Sociedad Medica de Santiago, 2023-05) Muñoz, Daniel; Cano, Catalina; Amador, Jorge; Vergara, Sandra; Ruiz, Guido; Vera, Claudia; Concha, Francisco; Morales, José; Fuentes, Yudith; Jara, Johana; López, Miguel; Martínez, José; Valenzuela, Valeria; Díaz, Claudia; Vásquez, Néstor; Torres, Sandra; Figueroa, Camila; Rocha, Daniela; Troncoso, Carla; Fuentes, Tatiana; Hernández, Rubén; Soto, Felipe; Klahn, Patricia; Sandoval, Rosa; Álvarez, Osvaldo; Bustamante, Beatriz; Castillo, Marcela; Mercado, Beatriz; Orellana, Cristian; Soto, Ricardo; Mollo, Julio; Espinoza, Sandra
    Background: The largest growth in cases of COVID-19 worldwide during 2020 was in the Americas, and Chile was one of the most affected countries. Aim: To describe, characterize, and evaluate the use of drugs as treatment for COVID-19 in hospitalized patients in Chile during the first wave of the pandemic. Methods: We performed a multicenter, observational study that included 442 patients with confirmed SARS-CoV-2 infection admitted in Chilean hospitals between March 21 and September 22, 2020. The analysis included demographics, comorbidities, specific drug therapy, and outcomes over a 28-day follow-up period. Results: The median age of patients was 68 years (IQR 55-73), and 38.9% were women. The most common comorbidities were hypertension (57.7%) and diabetes (36.9%). Fifty-seven (12.9%) patients died. Hypertension (HR 2.99; CI 95% 1.43-6.26) and age ≥ 65 (2.14; CI 95% 1.10- 4.17) were the main predictors of mortality. Primary drugs were azithromycin (58.8%) and corticosteroids (51.1%). In this sample, azithromycin was a protective factor regarding mortality (HR 0.53; CI 95% 0.31-0.90), increasing clinical improvement and avoiding progression. Conclusions: The patterns of use of drugs to treat COVID-19 in Chile during the first wave of the pandemic were very dynamic and followed the international, evidence-based guidelines. The low mortality rate indicates that the clinical management of hospitalized patients was adequate. © 2023 Sociedad Medica de Santiago. All rights reserved.