Examinando por Autor "Molina-Garcia, Pablo"

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    Association of sedentary behavior with brain structure and intelligence in children with overweight or obesity: The activebrains project
    (MDPI, 2024-04) Zavala-Crichton, Juan Pablo; Esteban-Cornejo, Irene; Solis-Urra, Patricio; Mora-Gonzalez, José; Cadenas-Sanchez, Cristina; Rodriguez-Ayllon, María; Migueles, Jairo H.; Molina-Garcia, Pablo; Verdejo-Roman, Juan; Kramer, Arthur F.; Hillman, Charles H.; Erickson, Kirk I.; Catena, Andrés; Ortega, Francisco B.
    We investigated the associations of different sedentary behaviors (SB) with gray matter volume and we tested whether SB related to gray matter volume is associated with intelligence. Methods: 99 children with overweight or obesity aged 8–11 years participated in this cross-sectional study. SB was measured using the Youth Activity Profile-Spain questionnaire. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Intelligence was assessed with the Kaufman Brief Test. Whole-brain voxel-wise multiple regression models were used to test the associations of each SB with gray matter volume. Results: Watching TV was associated with lower gray matter. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
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    Physical Performance and Amyloid-β in Humans: A Systematic Review and Meta-Analysis of Observational Studies
    (IOS Press BV, 2023-12-06) Solis-Urra, Patricio; Rodriguez-Ayllon, María; Álvarez-Ortega, Miriam; Molina-Hidalgo, Cristina; Molina-Garcia, Pablo; Arroyo-Ávila, Cristina; García-Hermoso, Antonio; Collins, Audrey M.; Jain, Shivangi; Gispert, Juan Domingo; Liu-Ambrose, Teresa; Ortega, Francisco B.; Erickson, Kirk I.; Esteban-Cornejo, Irene
    Background: Accumulation of amyloid-β (Aβ) plaques is one of the main features of Alzheimer's disease (AD). Physical performance has been related to dementia risk and Aβ, and it has been hypothesized as one of the mechanisms leading to greater accumulation of Aβ. Yet, no evidence synthesis has been performed in humans. Objective: To investigate the association of physical performance with Aβ in humans, including Aβ accumulation on brain, and Aβ abnormalities measured in cerebrospinal fluid (CSF) and blood. Methods: A systematic review with multilevel meta-analysis was performed from inception to June 16th, 2022. Studies were eligible if they examined the association of physical performance with Aβ levels, including the measure of physical performance as a predictor and the measure of Aβ as an outcome in humans. Results: 7 articles including 2,619 participants were included in the meta-analysis. The results showed that physical performance was not associated with accumulation of Aβ in the brain (ES = 0.01; 95% CI -0.21 to 0.24; I2 = 69.9%), in the CSF (ES = -0.28; 95% CI -0.98 to 0.41; I2 = 91.0%) or in the blood (ES = -0.19; 95% CI -0.61 to 0.24; I2 = 99.75%). Significant heterogeneity was found across the results , which posed challenges in arriving at consistent conclusions; and the limited number of studies hindered the opportunity to conduct a moderation analysis. Conclusions: The association between physical performance and Aβ is inconclusive. This uncertainly arises from the limited number of studies, study design limitations, and heterogeneity of measurement approaches. More studies are needed to determine whether physical performance is related to Aβ levels in humans.