Examinando por Autor "Morales, Francisco"
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Ítem Auditoría de estados financieros a sociedad Salmones Camanchaca(Universidad Andrés Bello, 2023) Morales, Francisco; Moya, Juan.; Pinto, Alejandra.; Valenzuela, Enrique; Facultad de Economía y Negocios; Escuela de Contador Auditor.El origen de la empresa salmonera se remonta a 1987, con la adquisición de una piscicultura en Polcura. Actualmente exportan pescados y mariscos a más de 50 países. Salmones Camanchaca SA corresponde a una empresa dedicada a la alimentación del mundo desde el mar, con productos saludables y nutritivos. Sus productos comercializados son: Salmón Atlántico, Salmón Coho, Trucha arcoíris. Salmones Camanchaca, promueve el desarrollo sostenible de la salmonicultura. Miembro fundador de la Global Salmon Initiative (GSI) y del Consejo de Comercialización del Salmón de Chile; así como el primer productor de salmón en obtener tres estrellas en la certificación de Mejores Prácticas Acuícolas (BAP). Hoy, cuenta con cuatro estrellas y fue la primera empresa salmonicultura en comprometerse a reducir las emisiones de carbono a cero para 2025. Las acciones de la empresa cotizan en la Bolsa de Oslo, el principal mercado de productos del mar del mundo, desde 2018. La Misión de la empresa es Alimentar al mundo desde el mar con proteínas saludables y nutritivas producidas bajo procesos sostenibles, y comprometidos con el medio ambiente y las comunidades en la cual la empresa está inserta. La administración de la compañía corresponde a un Directorio conformado por 7 miembros reelegibles. El presidente actual es el Sr. Jorge Fernández García.Ítem Mycoplasmateceae species are not found in Fallopian tubes of women with tubo-peritoneal infertility(Brazilian Society of Infectious Diseases, 2012) Costoya, Alberto; Morales, Francisco; Borda, Paula; Vargas, Renato; Fuhrer, Juan; Salgado, Nicole; Cárdenas, Hugo; Velasquez, LuisBACKGROUND: The role of mycoplasmas on the development and sequelae of pelvic inflammatory disease remains controversial. The objective of the present study is to correlate directly the presence of Mycoplasmateceae through polimerase chain reaction (PCR) determinations in cervix and Fallopian tubes of infertile patients with tubo-peritoneal factor diagnosed through laparoscopy. METHODS: Thirty patients with tubo-peritoneal infertility and 30 normal fertile patients were included in the study; cervical samples and tubal flushings were obtained during laparoscopy. PCR determinations for the detection of genetic material of Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma urealiticum, Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis in cervix and tubal flushings were performed. RESULTS: No Mycoplasmataceae species as "only" microorganisms were found in tubal flushings of tubo-peritoneal infertility patients, whereas three (10%) fertile patients with normal tubes were positive for mycoplasma presence. This difference was not significant (p = 0.237). Among the 30 patients suffering from tubal infertility diagnosed through laparoscopy, Mycoplasmatecae species were not detected in the Fallopian tubes by PCR determinations, while in normal tubes from fertile patients these and other microorganisms could be found without distorting tubal anatomy. CONCLUSION: Mycoplasmateceae species were not detected in Fallopian tubes of women with tubo-peritoneal infertility.Ítem Peptides and proteins used to enhance gold nanoparticle delivery to the brain: Preclinical approaches(Dove Medical Press Ltd., 2015-08) Velasco-Aguirre, Carolina; Morales, Francisco; Gallardo-Toledo, Eduardo; Guerrero, Simon; Giralt, Ernest; Araya, Eyleen; Kogan, Marcelo J.An exciting and emerging field in nanomedicine involves the use of gold nanoparticles (AuNPs) in the preclinical development of new strategies for the treatment and diagnosis of brain-related diseases such as neurodegeneration and cerebral tumors. The treatment of many brain-related disorders with AuNPs, which possess useful physical properties, is limited by the blood–brain barrier (BBB). The BBB highly regulates the substances that can permeate into the brain. Peptides and proteins may represent promising tools to improve the delivery of AuNPs to the central nervous system (CNS). In this review, we summarize the potential applications of AuNPs to CNS disorders, discuss different strategies based on the use of peptides or proteins to improve the delivery of AuNPs to the brain, and examine the intranasal administration route, which bypasses the BBB. We also analyze the potential neurotoxicity of AuNPs and the perspectives and new challenges concerning the use of peptides and proteins to enhance the delivery of AuNPs to the brain. The majority of the work described in this review is in a preclinical stage of experimentation, or in select cases, in clinical trials in humans. We note that the use of AuNPs still requires substantial study before being translated into human applications. However, for further clinical research, the issues related to the potential use of AuNPs must be analyzed. © 2015 Velasco-Aguirre et al.Ítem Superparamagnetic Poly (3-hydroxybutyrate-co-3 hydroxyvalerate) (PHBV) nanoparticles for biomedical applications(Pontificia Universidad Católica de Valparaíso, 2013) Vilos, Cristian; Gutiérrez, Marlen; Escobar, Roberto A.; Morales, Francisco; Denardin, Juliano C.; Velasquez, Luis; Altbir, DoraBackground: The progress in material science and the recent advances in biodegradable/biocompatible polymers and magnetic iron oxide nanoparticles have led to develop innovative diagnostic and therapeutic strategies for diseases based on multifunctional nanoparticles, which include contrast medium for magnetic resonance imaging, agent for hyperthermia and nanocarriers for targeted drug delivery. The aim of this work is to synthesize and characterize superparamagnetic iron oxide (magnetite), and to encapsulate them into poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles for biomedical applications. Results: The magnetite nanoparticles were confirmed by X-ray diffraction and exhibited a size of 22.3 ± 8.8 nm measured by transmission electron microscopy (TEM). Polymeric PHBV nanoparticles loaded with magnetite (MgNPs) were analyzed using dynamic light scattering and showed a size of 258.6 ± 35.7 nm and a negative zeta potential (-10.8 ± 3.5 mV). The TEM examination of MgNPs exhibited a spherical core-shell structure and the magnetic measurements showed in both, non-encapsulated magnetite and MgNPs, a superparamagnetic performance. Finally, the in vitro studies about the magnetic retention of MgNPs in a segment of small intestine of rats showed an active accumulation in the region of the magnetic field. Conclusions: The results obtained make the MgNPs suitable as potential magnetic resonance imaging contrast agents, also promoting hyperthermia and even as potential nanocarriers for site-specific transport and delivery of drugs. Keywords: hyperthermia, magnetic resonance image (MRI), magnetite, PHBV, polymeric nanoparticles.