Examinando por Autor "Morgan, R."

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    SOAR/Goodman Spectroscopic Assessment of Candidate Counterparts of the LIGO/Virgo Event GW190814
    (IOP Publishing Ltd, 2022-04-01) Tucker, D.L.; Wiesner, M.P.; Allam, S.S.; Soares-Santos, M.; Bom, C.R.; Butner, M.; Garcia, A.; Morgan, R.; Olivares, E. F.; Palmese, A.; Santana-Silva, L.; Shrivastava, A.; Annis, J.; García-Bellido, J.; Gill, M.S.S.; Herner, K.; Kilpatrick, C.D.; Makler, M.; Sherman, N.; Amara, A.; Lin, H.; Smith, M.; Swann, E.; Arcavi, I.; Bachmann, T.G.; Bechtol, K.; Berlfein, F.; Briceño, C.; Brout, D.; Butler, R.E.; Cartier, R.; Casares, J.; Chen, H.-Y.; Conselice, C.; Contreras, C.; Cook, E.; Cooke, J.; Dage, K.; D'Andrea, C.; Davis, T.M.; De Carvalho, R.; Diehl, H.T.; Dietrich, J.P.; Doctor, Z.; Drlica-Wagner, A.; Drout, M.; Farr, B.; Finley, D.A.; Fishbach, M.; Foley, R.J.; Förster-Burón, F.; Fosalba, P.; Friedel, D.; Frieman, J.; Frohmaier, C.; Gruendl, R.A.; Hartley, W.G.; Hiramatsu, D.; Holz, D.E.; Howell, D.A.; Kawash, A.; Kessler, R.; Kuropatkin, N.; Lahav, O.; Lundgren, A.; Lundquist, M.; Malik, U.; Mann, A.W.; Marriner, J.; Marshall, J.L.; Martínez-Vázquez, C.E.; McCully, C.; Menanteau, F.; Meza, N.; Narayan, G.; Neilsen, E.; Nicolaou, C.; Nichol, R.; Paz-Chinchón, F.; Pereira, M.E.S.; Pineda, J.; Points, S.; Quirola-Vásquez, J.; Rembold, S.; Rest, A.; Rodriguez, Ó.; Romer, A.K.; Sako, M.; Salim, S.; Scolnic, D.; Smith, J.A.; Strader, J.; Sullivan, M.; Swanson, M.E.C.; Thomas, D.; Valenti, S.; Varga, T.N.; Walker, A.R.; Weller, J.; Wood, M.L.; Yanny, B.; Zenteno, A.; Aguena, M.; Andrade-Oliveira, F.; Bertin, E.; Brooks, D.; Burke, D.L.; Rosell, A. Carnero; Kind, M. Carrasco; Carretero, J.; Costanzi, M.; Da Costa, L.N.; De Vicente, J.; Desai, S.; Everett, S.; Ferrero, I.; Flaugher, B.; Gaztanaga, E.; Gerdes, D.W.; Gruen, D.; Gschwend, J.; Gutierrez, G.; Hinton, S.R.; Hollowood, D.L.; Honscheid, K.; James, D.J.; Kuehn, K.; Lima, M.; Maia, M.A.G.; Miquel, R.; Ogando, R.L.C.; Pieres, A.; Plazas Malagón, A.A.; Rodriguez-Monroy, M.; Sanchez, E.; Scarpine, V.; Schubnell, M.; Serrano, S.; Sevilla-Noarbe, I.; Suchyta, E.; Tarle, G.; To, C.; Zhang, Y.
    On 2019 August 14 at 21:10:39 UTC, the LIGO/Virgo Collaboration (LVC) detected a possible neutron star-black hole merger (NSBH), the first ever identified. An extensive search for an optical counterpart of this event, designated GW190814, was undertaken using the Dark Energy Camera on the 4 m Victor M. Blanco Telescope at the Cerro Tololo Inter-American Observatory. Target of Opportunity interrupts were issued on eight separate nights to observe 11 candidates using the 4.1 m Southern Astrophysical Research (SOAR) telescope's Goodman High Throughput Spectrograph in order to assess whether any of these transients was likely to be an optical counterpart of the possible NSBH merger. Here, we describe the process of observing with SOAR, the analysis of our spectra, our spectroscopic typing methodology, and our resultant conclusion that none of the candidates corresponded to the gravitational wave merger event but were all instead other transients. Finally, we describe the lessons learned from this effort. Application of these lessons will be critical for a successful community spectroscopic follow-up program for LVC observing run 4 (O4) and beyond. © 2022. The Author(s). Published by the American Astronomical Society.
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    Targeting HOX-PBX interactions causes death in oral potentially malignant and squamous carcinoma cells but not normal oral keratinocytes
    (BioMed Central Ltd., 2018) Platais, C.; Radhakrishnan, R.; Ebensberger, S.N.; Morgan, R.; Lambert, D.W.; Hunter, K.D.
    Background: High HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggests that inhibition may be useful therapeutically. Inhibition of HOX protein binding to PBX cofactors by the use of synthetic peptides, such as HXR9, results in apoptosis in multiple cancers. Methods: Activity of the HOX-PBX inhibiting peptide HXR9 was tested in immortalised normal oral (NOK), potentially-malignant (PMOL) and squamous cell carcinoma (OSCC) cells, compared to the inactive peptide CXR9. Cytotoxicity was assessed by LDH assay. Expression of PBX1/2 and c-Fos was assessed by qPCR and western blotting. Apoptosis was assessed by Annexin-V assay. Results: PMOL and OSCC cells expressed PBX1/2. HOX-PBX inhibition by HXR9 caused death of PMOL and OSCC cells, but not NOKs. HXR9 treatment resulted in apoptosis and increased expression of c-Fos in some cells, whereas CXR9 did not. A correlation was observed between HOX expression and resistance to HXR9. Conclusion: Inhibition of HOX-PBX interactions causes selective apoptosis of OSCC/PMOL, indicating selective toxicity that may be useful clinically. © 2018 The Author(s).