Examinando por Autor "Olivares, P."

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    Calidad de sueño y rendimiento académico en alumnos de educación secundaria
    (Sociedad Médica de Santiago, 2017) Bugueño, M.; Curihual, C.; Olivares, P.; Wallace, J.; López-Alegría, F.; Rivera-López, G.; Oyanedel, J.C.
    Background: Sleeping and studying are the day-to-day activities of a teenager attending school. Aim: To determine the quality of sleep and its relationship to the academic performance among students attending morning and afternoon shifts in a public high school. Material and Methods: Students of the first and second year of high school answered an interview about socio-demographic background, academic performance, student activities and subjective sleep quality; they were evaluated using the Pittsburgh Sleep Quality Index (PSQI). Results: The interview was answered by 322 first year students aged 15 ± 5 years attending the morning shift and 364 second year students, aged 16 ± 0.5 years, attending the afternoon shift. The components: sleep latency, habitual sleep efficiency, sleep disturbance, drug use and daytime dysfunction were similar and classified as good in both school shifts. The components subjective sleep quality and duration of sleep had higher scores among students of the morning shift. The mean grades during the first semester of the students attending morning and afternoon shifts were 5.9 and 5.8, respectively (of a scale from 1 to 7). Among students of both shifts, the PSQI scale was associated inversely and significantly with academic performance. Conclusions: A bad sleep quality influences academic performance in these students.
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    Ítem
    Modeling hospital logistics capacity through system dynamics during the COVID-19 pandemic: case of Pasco Healthcare Network in Peru
    (Elsevier, 2024) Lock, R.; Benavente, Y.; Gatica, G.; Olivares, P.; Ramirez, J.; Gonzalez-Holgado, A.
    The present investigation, whose main objective is based on modeling the hospital logistics capacity in the Pasco Healthcare Network (Peru) through Systems Dynamics during the first and second wave of the appearance of the SARS-COVid-2 virus, oriented towards a study in the capacity to respond to the most intense health emergency in recent decades. In the first instance, the reality of the studied system was made known, which was possible thanks to the information provided by the actors that make up the hospital logistics capacity, sources uploaded to the WHO worldwide. Afterwards, we proceeded to characterize the variables that make up the system, prioritizing each of these through the application of a structural analysis that measured the levels of influence between one variable and another. Because of this, we proceeded to create the causal diagram, and likewise facilitate the inclusion of the network model through the Stella software. Once the model has been simulated, the results obtained are reported.
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    Novel TRPV1 Channel Agonists With Faster and More Potent Analgesic Properties Than Capsaicin
    (Frontiers Media S.A, 2020-07) Duarte, Y.; Cáceres, J.; Sepúlveda, R.V.; Arriagada, D.; Olivares, P.; Díaz-Franulic, I.; Stehberg, J.; González-Nilo, F.
    The transient receptor potential vanilloid 1 (TRPV1) ion channel is a member of the family of Transient Receptor Potential (TRP) channels that acts as a molecular detector of noxious signals in primary sensory neurons. Activated by capsaicin, heat, voltage and protons, it is also well known for its desensitization, which led to the medical use of topically applied TRPV1 agonist capsaicin for its long-lasting analgesic effects. Here we report three novel small molecules, which were identified using a Structure-Based Virtual Screening for TRPV1 from the ZINC database. The three compounds were tested using electrophysiological assays, which confirmed their capsaicin-like agonist activity. von Frey filaments were used to measure the analgesic effects of the compounds applied topically on tactile allodynia induced by intra-plantar carrageenan. All compounds had anti-nociceptive activity, but two of them showed faster and longer lasting analgesic effects than capsaicin. The present results suggest that TRPV1 agonists different from capsaicin could be used to develop topical analgesics with faster onset and more potent effects. © Copyright © 2020 Duarte, Cáceres, Sepúlveda, Arriagada, Olivares, Díaz-Franulic, Stehberg and González-Nilo.