Examinando por Autor "Olivares-Arancibia J."
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Ítem Association between Fractional Oxygen Extraction from Resting Quadriceps Muscle and Body Composition in Healthy Men(Multidisciplinary Digital Publishing Institute (MDPI), 2023-12) Yáñez-Sepúlveda, Rodrigo; Yáñez-Sepúlveda R.; Olivares-Arancibia, Jorge; Olivares-Arancibia J.; Cortés-Roco, Guillermo; Cortés-Roco G.; Vasquez-Bonilla, Aldo; Vasquez-Bonilla A.; Monsalves-Álvarez, Matías; Alvear-Órdenes, Ildefonso; Tuesta, MarceloThis study aimed to associate body composition with fractional oxygen extraction at rest in healthy adult men. Fourteen healthy adults (26.93 ± 2.49 years) from Chile participated. Body composition was assessed with octopole bioimpedance, and resting muscle oxygenation was evaluated in the vastus lateralis quadriceps with near-infrared spectroscopy (NIRS) during a vascular occlusion test, analyzing the muscleVO2, resaturation velocity during reactive hyperemia via the muscle saturation index (%TSI), and the area above the curve of HHb (AACrep). It was observed that the total and segmented fat mass are associated with lower reoxygenation velocities during hyperemia (p = 0.008; β = 0.678: p = 0.002; β = 0.751), and that the total and segmented skeletal muscle mass are associated with higher reoxygenation velocities during hyperemia (p = 0.020; β = −0.614: p = 0.027; β = −0.587). It was also observed that the total and segmented fat mass were associated with a higher area above the curve of HHb (AACrep) during hyperemia (p = 0.007; β = 0.692: p = 0.037; β = 0.564), and that total and segmented skeletal muscle mass was associated with a lower area above the curve of HHb (AACrep) during hyperemia (p = 0.007; β = −0.703: p = 0.017; β = −0.632). We concluded that fat mass is associated with lower resaturation rates and lower resting fractional O2 extraction levels. In contrast, skeletal muscle mass is associated with higher resaturation rates and fractional O2 extraction during reactive hyperemia. The AACrep may be relevant in the evaluation of vascular adaptations to exercise and metabolic health.Ítem The gut barrier, intestinal microbiota, and liver disease: Molecular mechanisms and strategies to manage(MDPI AG, 2020-11) Plaza-Díaz J.; Solís-Urra P.; Rodríguez-Rodríguez F.; Olivares-Arancibia J.; Navarro-Oliveros M.; Abadía-Molina F.; Álvarez-Mercado A.I.Liver disease encompasses pathologies as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, alcohol liver disease, hepatocellular carcinoma, viral hepatitis, and autoimmune hepatitis. Nowadays, underlying mechanisms associating gut permeability and liver disease development are not well understood, although evidence points to the involvement of intestinal microbiota and their metabolites. Animal studies have shown alterations in Toll-like receptor signaling related to the leaky gut syndrome by the action of bacterial lipopolysaccharide. In humans, modifications of the intestinal microbiota in intestinal permeability have also been related to liver disease. Some of these changes were observed in bacterial species belonging Roseburia, Streptococcus, and Rothia. Currently, numerous strategies to treat liver disease are being assessed. This review summarizes and discusses studies addressed to determine mechanisms associated with the microbiota able to alter the intestinal barrier complementing the progress and advancement of liver disease, as well as the main strategies under development to manage these pathologies. We highlight those approaches that have shown improvement in intestinal microbiota and barrier function, namely lifestyle changes (diet and physical activity) and probiotics intervention. Nevertheless, knowledge about how such modifications are beneficial is still limited and specific mechanisms involved are not clear. Thus, further in-vitro, animal, and human studies are needed. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.