Examinando por Autor "Solis-Urra, Patricio"
Mostrando 1 - 17 de 17
Resultados por página
Opciones de ordenación
Ítem Active gains in brain using exercise during aging (AGUEDA): protocol for a randomized controlled trial(Frontiers Media S.A., 2023) Solis-Urra, Patricio; Molina-Hidalgo, Cristina; García-Rivero, Yolanda; Costa-Rodriguez, Claudia; Mora-Gonzalez, Jose; Fernandez-Gamez, Beatriz; Olvera-Rojas, Marcos; Coca-Pulido, Andrea; Toval, Angel; Bellón, Darío; Sclafani, Alessandro; Martín-Fuentes, Isabel; Triviño-Ibañez, Eva María; de Teresa, Carlos; Huang, Haiqing; Grove, George; Hillman, Charles H.; Kramer, Arthur F.; Catena, Andrés; Ortega, Francisco B.; Gómez-Río, Manuel; Erickson, Kirk I.; Esteban-Cornejo, IreneAlzheimer’s disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent dementia risk. Physical exercise has been proposed as one of the leading non-pharmaceutical approaches to improve executive function and ameliorate cognitive decline. This single-site, two-arm, single-blinded, randomized controlled trial (RCT) will include 90 cognitively normal older adults, aged 65–80 years old. Participants will be randomized to a 24-week resistance exercise program (3 sessions/week, 60 min/session, n = 45), or a wait-list control group (n = 45) which will be asked to maintain their usual lifestyle. All study outcomes will be assessed at baseline and at 24-weeks after the exercise program, with a subset of selected outcomes assessed at 12-weeks. The primary outcome will be indicated by the change in an executive function composite score assessed with a comprehensive neuropsychological battery and the National Institutes of Health Toolbox Cognition Battery. Secondary outcomes will include changes in brain structure and function and amyloid deposition, other cognitive outcomes, and changes in molecular biomarkers assessed in blood, saliva, and fecal samples, physical function, muscular strength, body composition, mental health, and psychosocial parameters. We expect that the resistance exercise program will have positive effects on executive function and related brain structure and function, and will help to understand the molecular, structural, functional, and psychosocial mechanisms involved. Copyright © 2023 Solis-Urra, Molina-Hidalgo, García-Rivero, Costa-Rodriguez, Mora-Gonzalez, Fernandez-Gamez, Olvera-Rojas, Coca-Pulido, Toval, Bellón, Sclafani, Martín-Fuentes, Triviño-Ibañez, de Teresa, Huang, Grove, Hillman, Kramer, Catena, Ortega, Gómez-Río, Erickson and Esteban-Cornejo.Ítem Association of sedentary behavior with brain structure and intelligence in children with overweight or obesity: The activebrains project(MDPI, 2024-04) Zavala-Crichton, Juan Pablo; Esteban-Cornejo, Irene; Solis-Urra, Patricio; Mora-Gonzalez, José; Cadenas-Sanchez, Cristina; Rodriguez-Ayllon, María; Migueles, Jairo H.; Molina-Garcia, Pablo; Verdejo-Roman, Juan; Kramer, Arthur F.; Hillman, Charles H.; Erickson, Kirk I.; Catena, Andrés; Ortega, Francisco B.We investigated the associations of different sedentary behaviors (SB) with gray matter volume and we tested whether SB related to gray matter volume is associated with intelligence. Methods: 99 children with overweight or obesity aged 8–11 years participated in this cross-sectional study. SB was measured using the Youth Activity Profile-Spain questionnaire. T1-weighted images were acquired with a 3.0 T Magnetom Tim Trio system. Intelligence was assessed with the Kaufman Brief Test. Whole-brain voxel-wise multiple regression models were used to test the associations of each SB with gray matter volume. Results: Watching TV was associated with lower gray matter. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.Ítem Cardiac autonomic response during recovery using whole-body vibration after maximal cardiopulmonary exercise test(Federacion Espanola de Docentes de Educacion Fisica, 2021) Olivares-Arancibia, Jorge; Solis-Urra, Patricio; Porras-López, Felipe; Federeci-Diáz, Inti; Rodríguez-Rodríguez, Fernando; Pablo-Zavala, Juan; Cristi-Montero, CarlosIn the last years the nervous and cardiovascular response to exercise has taken on an important relevance, both in sport and health field. In this line, accelerating cardiovascular appears to play a key role in various sports fields. The study aims to examine and compare the acute effect of whole-body vibration (WBV) on cardiac autonomic response after maximal exercise in university runners and physical education student. Twenty men participated in a cross-over study, 10 university runners team (UR) and 10 physical education student (PES) with ages around 18 to 24 years. In each condition, was perform an incremental cardiopulmonary exercise test followed (i) active recovery time using WBV (25 Hz and peak displacement of four mm) and (ii) passive recovery period (no WBV; 0 Hz-0 mm), separated by seven days. Active recovery consisted in one minute seated using WBV and one minute no WBV by six times (12 minutes) more five minutes of passive recovery, and passive recovery consisted in 17 min seated on platform without vibration. Active recovery had significant differences compare to passive recovery (P<0.05). Furthermore, in active recovery, PES had better heart rate response than UR group, however results were not significative. There was not a clear relation between the lineal components of heart rate variability (HRV) in our results. WBV has positive effect in participant's recovery, however, is necessary establish protocols about the intensities and time adequate for allow accelerate recovery the parasympathetic reactivity, for that reason yet can't conclude clearly respect to the more effectivity intensity WBV depending to characteristic of subject. © 2021 Federación Espanõla de Asociaciones de Docentes de Educación Física (FEADEF).Ítem Cardiorespiratory fitness, physical activity, sedentary time and its association with the atherogenic index of plasma in chilean adults: Influence of the waist circumference to height ratio(MDPI, 2020-04) Reyes-Ferrada, Waleska; Solis-Urra, Patricio; Plaza-Díaz, Julio; Sadarangani, Kabir P.; Ferrari, Gerson Luis de Moraes; Rodríguez-Rodríguez, Fernando; Cristi-Montero, CarlosAtherogenic index of plasma (AIP) is a novel biomarker related to cardiovascular disease (CVD). Cardiorespiratory fitness (CRF) and physical activity (PA) have an inverse relationship with the AIP, while sedentary time (ST) and fatness present a positive association. This study aimed to determine the combined and independent association of CRF, PA, and ST with the AIP, and additionally to establish the waist-to-height ratio (WHtR) mediation role. Data from the Chilean national health survey were used (4671 adults). A PACS (Physical Activity Cardiorespiratory Sedentary) score was created ranging from 0 to 3, indicating the number of positive recommendations met (PA, ST, and CRF). AIP was calculated (Log10 triglycerides/high-density lipoprotein-cholesterol). The combined analysis showed that compared to those with a PACS score of 0, those with a score of 1 or 2 did not present significantly reduced AIP values (adjusted by the WHtR); however, those with a score of 3 did (OR (odds ratio) = 0.50; 95% CI, 0.32 to 0.77; p < 0.001). Independent analysis showed that CRF seems to be the only variable that supports the combined result (β = −0.212; p < 0.001). Finally, the mediation analysis indicated that the WHtR mediated the association between CRF and the AIP in 34.2% of cases. Overall, only CRF had a significant and inverse association with the AIP. Nonetheless, around one-third of this beneficial relationship is affected by an elevated WHtR. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.Ítem Could physical fitness be considered as a protective social factor associated with bridging the cognitive gap related to school vulnerability in adolescents? The cogni-action project(MDPI, 2021-09) Cristi-Montero, Carlos; Ibarra-Mora, Jessica; Gaya, Anelise; Castro-Piñero, Jose; Solis-Urra, Patricio; Aguilar-Farias, Nicolas; Ferrari, Gerson; Rodriguez-Rodriguez, Fernando; Sadarangani, Kabir P.The first aim was to compare differences between school vulnerability groups, fitness levels, and their combination in adolescent cognitive performance. The second aim was to determine the mediation role of fitness in the association between school vulnerability and cognitive performance. A total of 912 Chilean adolescents aged 10–14 years participated in this study. The school vulnerability index (SVI) assigned by the Chilean Government was categorized into high-, mid-, or low-SVI. Adolescents were classified as fit or unfit according to their global fitness z-score computed from their cardiorespiratory (CRF), muscular (MF), and speed/agility fitness (SAF) adjusted for age and sex. A global cognitive score was estimated through eight tasks based on a neurocognitive battery. Covariance and mediation analyses were performed, adjusted for sex, schools, body mass index, and peak high velocity. Independent analyses showed that the higher SVI, the lower the cognitive performance (F(6,905) = 18.5; p < 0.001). Conversely, fit adolescents presented a higher cognitive performance than their unfit peers (F(5,906) = 8.93; p < 0.001). The combined analysis found cognitive differences between fit and unfit adolescents in both the high-and mid-SVI levels (Cohen’s d = 0.32). No differences were found between fit participants belonging to higher SVI groups and unfit participants belonging to lower SVI groups. Mediation percentages of 9.0%, 5.6%, 7.1%, and 2.8% were observed for the global fitness score, CRF, MF, and SAF, respectively. The mediation effect was significant between low-with mid-high-SVI levels but not between mid-and high-SVI levels. These findings suggest that an adequate physical fitness level should be deemed a protective social factor associated with bridging the cognitive gap linked to school vulnerability in adolescents. This favourable influence seems to be most significant in adolescents belonging to a more adverse social background. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Ítem Early life factors and white matter microstructure in children with overweight and obesity: The ActiveBrains project(Churchill Livingstone, 2022-01) Solis-Urra, Patricio; Esteban-Cornejo, Irene; Rodriguez-Ayllon, María; Verdejo-Román, Juan; Labayen, Idoia; Catena, Andrés; Ortega, Francisco B.Background & aims: Exposure to a suboptimal environment during the fetal and early infancy period's results in long-term consequences for brain morphology and function. We investigated the associations of early life factors such as anthropometric neonatal data (i.e., birth length, birth weight and birth head circumference) and breastfeeding practices (i.e., exclusive and any breastfeeding) with white matter (WM) microstructure, and ii) we tested whether WM tracts related to early life factors are associated with academic performance in children with overweight/obesity. Methods: 96 overweight/obese children (10.03 ± 1.16 years; 38.7% girls) were included from the ActiveBrains Project. WM microstructure indicators used were fractional anisotropy (FA) and mean diffusivity (MD), derived from Diffusion Tensor Imaging. Academic performance was evaluated with the Battery III Woodcock–Muñoz Tests of Achievement. Regression models were used to examine the associations of the early life factors with tract-specific FA and MD, as well as its association with academic performance. Results: Head circumference at birth was positively associated with FA of the inferior fronto-occipital fasciculus tract (0.441; p = 0.005), as well as negatively associated with MD of the cingulate gyrus part of cingulum (−0.470; p = 0.006), corticospinal (−0.457; p = 0.005) and superior thalamic radiation tract (−0.476; p = 0.001). Association of birth weight, birth length and exclusive breastfeeding with WM microstructure did not remain significant after false discovery rate correction. None tract related to birth head circumference was associated with academic performance (all p > 0.05). Conclusions: Our results highlighted the importance of the perinatal growth in WM microstructure later in life, although its possible academic implications remain inconclusive. © 2021 The Author(s)Ítem Effect of High-Intensity whole body vibration on blood lactate removal and heart rate after an all-out test in active young men(Retos, Issue 39, Pages 471 - 4762021, 2021) Galaz-Campos, Daniel; Olivares-Arancibia, Jorge; Solis-Urra, Patricio; Suarez-Cadenas, Ernesto; Santos-Lozano, Alejandro; Rodríguez-Rodríguez, Fernando; Cristi-Montero, CarlosSpeed up recovery is fundamental in sport disciplines in which competitors must perform repeated trials within the same competition. The main objective of this study was to determine the effect of high-frequency whole body vibration (WBV) on blood [Lac] removal and heart rate (HR) after an all-out test. The participants performed a 4 x 100 m all-out test every 48 h in a random cross-over fashion, and a blood [Lac] removal protocol was applied after each test: a) 20 min seated (REST); b) squatting on a vibrating platform (S+V); and c) squatting on a non-vibrating platform (S-V). Blood [Lac] and HR were measured at rest, immediately after the 4 x 100 m all-out test (min 0), and at 10 and 20 min during the removal protocols. The results showed that the 3 protocols displayed significantly decreased blood [Lac] after 20 min (REST, S+V, and S-V removed Δ 6.6; Δ 10.5; and Δ 11.1 mmol•L-1, respectively). However, there were no significant differences in the blood [Lac] removal level between the S+V and S-V conditions. Interestingly, the S-V participants showed increased HR levels during the active recovery compared with the REST and S+V conditions. The effect of high-frequency WBV is not an additional stimulus to increase the blood [Lac] removal capacity in active young men, although WBV appeared to elicit less cardiovascular stress during recovery. © Copyright: Federación Española de Asociaciones de Docentes de Educación Física (FEADEF)Ítem Examining Elastic Band Properties for Exercise Prescription: AGUEDA Equations(John Wiley and Sons Ltd, 2025-01) Fernandez-Gamez, Beatriz; Pulido-Muñoz, Álvaro; Olvera-Rojas, Marcos; Solis-Urra, Patricio; Corral-Pérez, Juan; Morales, Javier S.; Jiménez-Pavón, David; Mora-Gonzalez, JoseThe objective of this paper is to quantify muscle load using Theraband elastic bands across seven resistance intensities. Methods: Bands were profiled using a force sensor, standardized to 200 cm length, and manually stretched. Measurements for each band were twice recorded at 11 distances and converted to percentages for standardization. Results: Equations derived from Theraband resistance properties were established (kg = ((elastic constant) ± SE) × percentage of elongation). The standard error ranged from 0.0007 to 0.069, while the coefficient of determination ranged from 0.977 to 0.995. Conclusion: This study provides quantification of resistance across various intensities of Theraband elastic band, offering equations for estimating external load.Ítem Insights into the impact of microbiota in the treatment of nafld/nash and its potential as a biomarker for prognosis and diagnosis(22279059, 2021-02) Plaza-Díaz, Julio; Solis-Urra, Patricio; Aragón-Vela, Jerónimo; Rodríguez-Rodríguez, Fernando; Olivares-Arancibia, Jorge; Álvarez-Mercado, I.Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of chronic liver illness associated with obesity and metabolic disorders, such as hypertension, dyslipidemia, or type 2 diabetes mellitus. A more severe type of NAFLD, non-alcoholic steatohepatitis (NASH), is considered an ongoing global health threat and dramatically increases the risks of cirrhosis, liver failure, and hepatocellular carcinoma. Several reports have demonstrated that liver steatosis is associated with the elevation of certain clinical and biochemical markers but with low predictive potential. In addition, current imaging methods are inaccurate and inadequate for quantification of liver steatosis and do not distinguish clearly between the microvesicular and the macrovesicular types. On the other hand, an unhealthy status usually presents an altered gut microbiota, associated with the loss of its functions. Indeed, NAFLD pathophysiology has been linked to lower microbial diversity and a weakened intestinal barrier, exposing the host to bacterial components and stimulating pathways of immune defense and inflammation via toll-like receptor signaling. Moreover, this activation of inflammation in hepatocytes induces progression from simple steatosis to NASH. In the present review, we aim to: (a) summarize studies on both human and animals addressed to determine the impact of alterations in gut microbiota in NASH; (b) evaluate the potential role of such alterations as biomarkers for prognosis and diagnosis of this disorder; and (c) discuss the involvement of microbiota in the current treatment for NAFLD/NASH (i.e., bariatric surgery, physical exercise and lifestyle, diet, probiotics and prebiotics, and fecal microbiota transplantation). © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Ítem Passive commuting and higher sedentary time is associated with vitamin D deficiency in adult and older women: Results from Chilean National Health Survey 2016–2017(Nutrients, 2019) Solis-Urra, Patricio; Cristi-Montero, Carlos; Romero-Parra, Javier; Zavala-Crichton, Juan Pablo; Saez-Lara, Maria Jose; Plaza-Diaz, JulioThe aim was to investigate the associations between different physical activity (PA) patterns and sedentary time (ST) with vitamin D deficiency (<12 ng/mL) in a large sample of Chilean women. In this cross-sectional study, the final sample included 1245 adult and 686 older women. The PA levels, mode of commuting, ST, and leisure-time PA were self-reported. Vitamin D deficiency was defined as <12 ng/mL and insufficiency as <20 ng/mL. A higher ST was associated with vitamin D deficiency (odds ratio (OR): 2.4, 95%: 1.6–4.3) in adults, and passive commuting was associated with vitamin D deficiency in older (OR: 1.7, 95%: 1.1–2.7). Additionally, we found a joint association in the high ST/passive commuting group in adults (OR: 2.8, 95%: 1.6–4.9) and older (OR: 2.8, 95%: 1.5–5.2) with vitamin D deficiency, in respect to low ST/active commuting. The PA levels and leisure-time PA were not associated with vitamin D deficiency. In conclusion, mode of commuting and ST seems important variables related to vitamin D deficiency. Promoting a healthy lifestyle appears important also for vitamin D levels in adult and older women. Further studies are needed to establish causality of this association and the effect of vitamin D deficiency in different diseases in this population. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.Ítem Physical Activity, Gut Microbiota, and Genetic Background for Children and Adolescents with Autism Spectrum Disorder(Multidisciplinary Digital Publishing Institute (MDPI), 2022-12) Plaza-Diaz, Julio; Radar, Ana Mei; Baig, Aiman Tariq; Leyba, Marcos Federico; Costabel, Maria Macarena; Zavala-Crichton, Juan Pablo; Sanchez-Martinez, Javier; MacKenzie, Alex E.; Solis-Urra, PatricioIt is estimated that one in 100 children worldwide has been diagnosed with autism spectrum disorder (ASD). Children with ASD frequently suffer from gut dysbiosis and gastrointestinal issues, findings which possibly play a role in the pathogenesis and/or severity of their condition. Physical activity may have a positive effect on the composition of the intestinal microbiota of healthy adults. However, the effect of exercise both on the gastrointestinal problems and intestinal microbiota (and thus possibly on ASD) itself in affected children is unknown. In terms of understanding the physiopathology and manifestations of ASD, analysis of the gut–brain axis holds some promise. Here, we discuss the physiopathology of ASD in terms of genetics and microbiota composition, and how physical activity may be a promising non-pharmaceutical approach to improve ASD-related symptoms. © 2022 by the authors.Ítem Physical Performance and Amyloid-β in Humans: A Systematic Review and Meta-Analysis of Observational Studies(IOS Press BV, 2023-12-06) Solis-Urra, Patricio; Rodriguez-Ayllon, María; Álvarez-Ortega, Miriam; Molina-Hidalgo, Cristina; Molina-Garcia, Pablo; Arroyo-Ávila, Cristina; García-Hermoso, Antonio; Collins, Audrey M.; Jain, Shivangi; Gispert, Juan Domingo; Liu-Ambrose, Teresa; Ortega, Francisco B.; Erickson, Kirk I.; Esteban-Cornejo, IreneBackground: Accumulation of amyloid-β (Aβ) plaques is one of the main features of Alzheimer's disease (AD). Physical performance has been related to dementia risk and Aβ, and it has been hypothesized as one of the mechanisms leading to greater accumulation of Aβ. Yet, no evidence synthesis has been performed in humans. Objective: To investigate the association of physical performance with Aβ in humans, including Aβ accumulation on brain, and Aβ abnormalities measured in cerebrospinal fluid (CSF) and blood. Methods: A systematic review with multilevel meta-analysis was performed from inception to June 16th, 2022. Studies were eligible if they examined the association of physical performance with Aβ levels, including the measure of physical performance as a predictor and the measure of Aβ as an outcome in humans. Results: 7 articles including 2,619 participants were included in the meta-analysis. The results showed that physical performance was not associated with accumulation of Aβ in the brain (ES = 0.01; 95% CI -0.21 to 0.24; I2 = 69.9%), in the CSF (ES = -0.28; 95% CI -0.98 to 0.41; I2 = 91.0%) or in the blood (ES = -0.19; 95% CI -0.61 to 0.24; I2 = 99.75%). Significant heterogeneity was found across the results , which posed challenges in arriving at consistent conclusions; and the limited number of studies hindered the opportunity to conduct a moderation analysis. Conclusions: The association between physical performance and Aβ is inconclusive. This uncertainly arises from the limited number of studies, study design limitations, and heterogeneity of measurement approaches. More studies are needed to determine whether physical performance is related to Aβ levels in humans.Ítem Study protocol and rationale of the "cogni-action project" a cross-sectional and randomized controlled trial about physical activity, brain health, cognition, and educational achievement in schoolchildren(BioMed Central Ltd, 2019-07-26) Solis-Urra, Patricio; Olivares-Arancibia, Jorge; Suarez-Cadenas, Ernesto; Sanchez-Martinez, Javier; Rodríguez-Rodríguez, Fernando; Ortega, Francisco B.; Esteban-Cornejo, Irene; Cadenas-Sanchez, Cristina; Castro-Piñero, Jose; Veloz, Alejandro; Chabert, Steren; Saradangani, Kabir P.; Zavala-Crichton, Juan Pablo; Migueles, Jairo H.; Mora-Gonzalez, Jose; Quiroz-Escobar, Milton; Almonte-Espinoza, Diego; Urzúa, Alfonso; Dragicevic, Constantino D.; Astudillo, Aland; Méndez-Gassibe, Eduardo; Riquelme-Uribe, Daniel; Azagra, Marcela Jarpa; Cristi-Montero, CarlosBackground: Education and health are crucial topics for public policies as both largely determine the future wellbeing of the society. Currently, several studies recognize that physical activity (PA) benefits brain health in children. However, most of these studies have not been carried out in developing countries or lack the transference into the education field. The Cogni-Action Project is divided into two stages, a cross-sectional study and a crossover-randomized trial. The aim of the first part is to establish the associations of PA, sedentarism, and physical fitness with brain structure and function, cognitive performance and academic achievement in Chilean schoolchildren (10-13 years-old). The aim of the second part is to determinate the acute effects of three PA protocols on neuroelectric indices during a working memory and a reading task. Methods: PA and sedentarism will be self-reported and objectively-assessed with accelerometers in a representative subsample, whilst physical fitness will be evaluated through the ALPHA fitness test battery. Brain structure and function will be assessed by magnetic resonance imaging (MRI) in a randomized subsample. Cognitive performance will be assessed through the NeuroCognitive Performance Test, and academic achievement by school grades. In the second part 32 adolescents (12-13 year-old) will be cross-over randomized to these condition (i) "Moderate-Intensity Continuous Training" (MICT), (ii) "Cooperative High-Intensity Interval Training" (C-HIIT), and (iii) Sedentary condition. Neuroelectric indices will be measures by electroencephalogram (EEG) and eye-tracking, working memory by n-back task and reading comprehension by a reading task. Discussion: The main strength of this project is that, to our knowledge, this is the first study analysing the potential association of PA, sedentarism, and physical fitness on brain structure and function, cognitive performance, and academic achievement in a developing country, which presents an important sociocultural gap. For this purpose, this project will use advanced technologies in neuroimaging (MRI), electrophysiology (EEG), and eye-tracking, as well as objective and quality measurements of several physical and cognitive health outcomes. Trial registration: ClinicalTrials.gov identifier: NCT03894241 Date of register: March 28, 2019. Retrospectively Registered. © 2019 The Author(s).Ítem The effects of an exercise intervention on neuroelectric activity and executive function in children with overweight/obesity: The ActiveBrains randomized controlled trial(John Wiley and Sons Inc, 2024-01) Mora-Gonzalez, Jose; Esteban-Cornejo, Irene; Solis-Urra, Patricio; Rodriguez-Ayllon, María; Cadenas-Sanchez, Cristina; Hillman, Charles H.; Kramer, Arthur F.; Catena, Andrés; Ortega, Francisco B.Objective: To investigate whether a 20-week aerobic and resistance exercise program induces changes in brain current density underlying working memory and inhibitory control in children with overweight/obesity. Methods: A total of 67 children (10.00 ± 1.10 years) were randomized into an exercise or control group. Electroencephalography (EEG)-based current density (μA/mm2) was estimated using standardized low-resolution brain electromagnetic tomography (sLORETA) during a working memory task (Delayed non-matched-to-sample task, DNMS) and inhibitory control task (Modified flanker task, MFT). In DNMS, participants had to memorize four stimuli (Pokemons) and then select between two of them, one of which had not been previously shown. In MFT, participants had to indicate whether the centered cow (i.e., target) of five faced the right or left. Results: The exercise group had significantly greater increases in brain activation in comparison with the control group during the encoding phase of DNMS, particularly during retention of second stimuli in temporal and frontal areas (peak t = from 3.4 to 3.8, cluster size [k] = from 11 to 39), during the retention of the third stimuli in frontal areas (peak t = from 3.7 to 3.9, k = from 15 to 26), and during the retention of the fourth stimuli in temporal and occipital areas (peak t = from 2.7 to 4.3, k = from 13 to 101). In MFT, the exercise group presented a lower current density change in the middle frontal gyrus (peak t = −4.1, k = 5). No significant change was observed between groups for behavioral performance (p ≥ 0.05). Conclusion: A 20-week exercise program modulates brain activity which might provide a positive influence on working memory and inhibitory control in children with overweight/obesity. © 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.Ítem The effects of physical activity on white matter microstructure in children with overweight or obesity: The ActiveBrains randomized clinical trial(Elsevier B.V., 2024-01) Rodriguez-Ayllon, Maria; Verdejo-Roman, Juan; Lesnovskaya, Alina; Mora-Gonzalez, Jose; Solis-Urra, Patricio; Catena, Andrés; Erickson, Kirk I.; Ortega, Francisco B; Esteban-Cornejo, IreneBackground: Emerging research supports the idea that physical activity benefits brain development. However, the body of evidence focused on understanding the effects of physical activity on white matter microstructure during childhood is still in its infancy, and further well-designed randomized clinical trials are needed. Aim: This study aimed: (i) to investigate the effects of a 20-week physical activity intervention on global white matter microstructure in children with overweight or obesity, and (ii) to explore whether the effect of physical activity on white matter microstructure is global or restricted to a particular set of white matter bundles. Methods: In total, 109 children aged 8 to 11 years with overweight or obesity were randomized and allocated to either the physical activity program or the control group. Data were collected from November 2014 to June 2016, with diffusion tensor imaging (DTI) data processing and analyses conducted between June 2017 and November 2021. Images were pre-processed using the Functional Magnetic Resonance Imaging (MRI) of the Brain´s Software Library (FSL) and white matter properties were explored by probabilistic fiber tractography and tract-based spatial statistics (TBSS). Results: Intention-to-treat analyses were performed for all children who completed the pre-test and post-test DTI assessment, with good quality DTI data (N = 89). Of them, 83 children (10.06±1.11 years, 39 % girls, intervention group=44) met the per-protocol criteria (attended at least 70 % of the recommended sessions). Our probabilistic fiber tractography analysis did not show any effects in terms of global and tract-specific fractional anisotropy (FA) and mean diffusivity (MD) in the per-protocol or intention-to-treat analyses. Additionally, we did not observe any effects on the voxel-wise DTI parameters (i.e., FA and MD) using the most restricted TBSS approach (i.e., per protocol analyses and p-corrected image with a statistical threshold of p < 0.05). In the intention-to-treat analysis, we found that our physical activity program had a borderline effect (p-corrected image with a statistical threshold of p < 0.1) on 7 different clusters, including a cluster in the corpus callosum. Conclusion: We conclude that a 20-week physical activity intervention was not enough to induce changes in global and tract-specific white matter during childhood. The effects of physical activity on white matter microstructure could be restricted to local changes in several white matter tracts (e.g., the body of the corpus callosum). However, our results were not significant, and more interventions are needed to determine whether and how physical activity affects white matter microstructure during childhood. © 2023 The AuthorsÍtem The mediation effect of self–report physical activity patterns in the relationship between educational level and cognitive impairment in elderly: A cross-sectional analysis of chilean health national survey 2016–2017(MDPI, 2020-04) Solis-Urra, Patricio; Plaza-Diaz, Julio; Álvarez-Mercado, Ana Isabel; Rodríguez-Rodríguez, Fernando; Cristi-Montero, Carlos; Zavala-Crichton, Juan Pablo; Olivares-Arancibia, Jorge; Sanchez-Martinez, Javier; Abadía-Molina, FranciscoThe aims of this cross-sectional study were (i) to determine the association of educational level attained with cognitive impairment and (ii) to investigate the mediating effect of different self-report physical activity (PA) patterns in a large sample of older Chileans. A sample of 1571 older adults from the National Chilean Survey (2016–2017) was included. The educational level attained, PA levels, mode of commuting, sedentary time, and leisure-time PA were self-reported through validated questionnaires. Cognitive impairment was determined by Mini-Mental State Examination (modified version). Association between educational level attained and cognitive impairment was examined using logistic regression models. Counterfactual mediation models were used to test the mediating effect of self-reported PA patterns. A lower educational level was consistently associated with higher odds of cognitive impairment (OR range 2.846 to 2.266, all p < 0.001), while leisure-time PA was the only PA pattern that partially mediated this association (proportion mediated 8.0%). In conclusion, leisure-time PA was the solely PA pattern that partially mediated the association between the educational level and cognitive impairment. The rest self-reported PA patterns did not modify this association. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.Ítem Which indices of cardiorespiratory fitness are more strongly associated with brain health in children with overweight/obesity?(John Wiley and Sons Inc, 2024-01) Haapala, Eero A.; Lubans, David R.; Jaakkola, Timo; Barker, Alan R.; Plaza-Florido, Abel; Gracia-Marco, Luis; Solis-Urra, Patricio; Cadenas-Sanchez, Cristina; Esteban-Cornejo, Irene; Ortega, Francisco B.Purpose: To compare the strength of associations between different indicesof cardiorespiratory fitness (CRF) and brain health outcomes in children withoverweight/obesity.Methods: Participants were 100 children aged 8–11 years. CRF was assessedusing treadmill exercise test (peak oxygen uptake [V̇O 2peak], treadmill time, andV̇O 2 at ventilatory threshold) and 20-metre shuttle run test (20mSRT, laps, run-ning speed, estimated V̇O 2peak using the equations by Léger et al., Mahar et al.,and Matsuzaka et al.). Intelligence, executive functions, and academic perfor-mance were assessed using validated methods. Total gray matter and hippocam-pal volumes were assessed using structural MRI.Results: V̇O 2peak/body mass (β = 0.18, 95% CI = 0.01–0.35) and treadmill time(β = 0.18–0.21, 95% CI = 0.01–0.39) were positively associated with gray mat-ter volume. 20mSRT laps were positively associated with executive functions (β = 0.255, 95% CI = 0.089–0.421) and academic performance (β = 0.199–0.255, 95%CI = 0.006–0.421), and the running speed was positively associated with executivefunctions (β = 0.203, 95% CI = 0.039–0.367). Estimated V̇O2peak/Léger et al. was posi-tively associated with intelligence, executive functions, academic performance,and gray matter volume (β = 0.205–0.282, 95% CI = 0.013–0.500). EstimatedV̇O 2peak/Mahar et al. and V̇O 2peak/Matsuzaka et al. (speed) were positively associated withexecutive functions (β = 0.204–0.256, 95% CI = 0.031–0.436).Conclusion: Although V̇O2peak is considered the gold standard indicator ofCRF in children, peak performance (laps or running speed) and estimatedV̇O 2peak/Léger et al. derived from 20mSRT had stronger and more consistent asso-ciations with brain health outcomes than other indices of CRF in children withoverweight/obesity