Examinando por Autor "Taborga Liber, Lautaro"

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    Synthesis of nine safrole derivatives and their antiproliferative activity towards human cancer cells
    (Sociedad Chilena de Química, 2010) Espinoza Catalán, Luis; Madrid Villegas, Alejandro; Taborga Liber, Lautaro; Villena García, Joan; Cuellar Fritis, Mauricio; Carrasco Altamirano, Héctor
    Safrole from sassafras oil (Ocoteapretiosa Mez., Lauraceae), is an abundant natural product showing interesting functionality and chemical structure. Starting from safrole, nine derivatives were prepared and assessed for antiproliferative effect using different human cell lines. The in vitro growth inhibition assay was based on the sulphorhodamine dye to quantify cell viability. Some safrole derivatives, (2E')-3-(3',4'-methylenedioxi)phenyl acrylaldehyde (3) and 4-allyl-5-nitrobenzene-1,2-diol (4) presented better antiproliferative effect than the parent compound on two breast cancer cell lines (MCF-7 and MDA-MB-231) and one human colorectal cancer cell line (DLD-1) with IC50 values of 55.0 + 7.11 uM, 37.5 +2.65 uM and 44.0 + 6.92 µM, respectively, without toxicity towards dermal human fibroblast (DHF cells).