Examinando por Autor "Valenzuela, M."

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    Biopesticide activity from drimanic compounds to control tomato pathogens
    (MDPI AG, 2018-08) Montenegro, I.; Madrid, A.; Cuellar, M.; Seeger, M.; Alfaro, J.F.; Besoain, X.; Martínez, J.P.; Ramirez, I.; Olguín, Y.; Valenzuela, M.
    Tomato crops can be affected by several infectious diseases produced by bacteria, fungi, and oomycetes. Four phytopathogens are of special concern because of the major economic losses they generate worldwide in tomato production; Clavibacter michiganensis subsp. michiganensis and Pseudomonas syringae pv. tomato, causative agents behind two highly destructive diseases, bacterial canker and bacterial speck, respectively; fungus Fusarium oxysporum f. sp. lycopersici that causes Fusarium Wilt, which strongly affects tomato crops; and finally, Phytophthora spp., which affect both potato and tomato crops. Polygodial (1), drimenol (2), isonordrimenone (3), and nordrimenone (4) were studied against these four phytopathogenic microorganisms. Among them, compound 1, obtained from Drimys winteri Forst, and synthetic compound 4 are shown here to have potent activity. Most promisingly, the results showed that compounds 1 and 4 affect Clavibacter michiganensis growth at minimal inhibitory concentrations (MIC) values of 16 and 32 μg/mL, respectively, and high antimycotic activity against Fusarium oxysporum and Phytophthora spp. with MIC of 64 μg/mL. The results of the present study suggest novel treatment alternatives with drimane compounds against bacterial and fungal plant pathogens. © 2018 by the authors.
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    Solid state pathways to complex shape evolution and tunable porosity during metallic crystal growth
    (Nature Publishing Group, 2013-09) Valenzuela, C.; Carriedo, G.; Valenzuela, M.; Zúñiga, L.; O'Dwyer, C.
    Growing complex metallic crystals, supported high index facet nanocrystal composites and tunable porosity metals, and exploiting factors that influence shape and morphology is crucial in many exciting developments in chemistry, catalysis, biotechnology and nanoscience. Assembly, organization and ordered crystallization of nanostructures into complex shapes requires understanding of the building blocks and their association, and this relationship can define the many physical properties of crystals and their assemblies. Understanding crystal evolution pathways is required for controlled deposition onto surfaces. Here, complex metallic crystals on the nano- and microscale, carbon supported nanoparticles, and spinodal porous noble metals with defined inter-feature distances in 3D, are accomplished in the solid-state for Au, Ag, Pd, and Re. Bottom-up growth and positioning is possible through competitive coarsening of mobile nanoparticles and their site-specific crystallization in a nucleation-dewetted matrix. Shape evolution, density and growth mechanism of complex metallic crystals and porous metals can be imaged during growth.
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    Synthesis and antiproliferative activity of new cyclodiprenyl phenols against select cancer cell lines
    (MDPI AG, 2018-09) Said, B.; Montenegro, I.; Valenzuela, M.; Olguín, Y.; Caro, N.; Werner, E.; Godoy, P.; Villena, J.; Madrid, A.
    Six new cyclodiprenyl phenols were synthesized by direct coupling of perillyl alcohol and the appropriate phenol. Their structures were established by IR, HRMS and mainly NMR. Three human cancer cell lines-breast (MCF-7), prostate (PC-3) and colon (HT-29)-were used in antiproliferative assays, with daunorubicin and dunnione as positive controls. Results described in the article suggest that dihydroxylated compounds 2-4 and monohydroxylated compound 5 display selectivity against cancer cell lines, cytotoxicity, apoptosis induction, and mitochondrial membrane impairment capacity. Compound 2 was identified as the most effective of the series by displaying against all cancer cell lines a cytotoxicity close to dunnione antineoplastic agent, suggesting that the cyclodiprenyl phenols from perillyl alcohol deserve more extensive investigation of their potential medicinal applications. © 2018 by the authors.
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    Three-dimensional fractional-spin gravity
    (Springer, 2014-02) Boulanger, N.; Sundell, P.; Valenzuela, M.
    Using Wigner-deformed Heisenberg oscillators, we construct 3D Chern-Simons models consisting of fractional-spin fields coupled to higher-spin gravity and internal nonabelian gauge fields. The gauge algebras consist of Lorentz-tensorial Blencowe-Vasiliev higher-spin algebras and compact internal algebras intertwined by infinite-dimensional generators in lowest-weight representations of the Lorentz algebra with fractional spin. In integer or half-integer non-unitary cases, there exist truncations to gl(ℓ, ℓ ± 1) or gl(ℓ|ℓ ± 1) models. In all non-unitary cases, the internal gauge fields can be set to zero. At the semi-classical level, the fractional-spin fields are either Grassmann even or odd. The action requires the enveloping-algebra representation of the deformed oscillators, while their Fock-space representation suffices on-shell.