Examinando por Autor "Valladares-Ide, Denisse"

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    Changes in Blood Markers of Oxidative Stress, Inflammation and Cardiometabolic Patients with COPD after Eccentric and Concentric Cycling Training
    (MDPI, 2023-02) Valero-Breton, Mayalen; Valladares-Ide, Denisse; Álvarez, Cristian; Peñailillo, Reyna S.; Peñailillo, Luis
    Chronic obstructive pulmonary disease (COPD) patients manifest muscle dysfunction and impaired muscle oxidative capacity, which result in reduced exercise capacity and poor health status. This study examined the effects of 12-week eccentric (ECC) and concentric (CONC) cycling training on plasma markers of cardiometabolic health, oxidative stress, and inflammation in COPD patients. A randomized trial in which moderate COPD was allocated to ECC (n = 10; 68.2 ± 10.0 year) or CONC (n = 10; 71.1 ± 10.3 year) training groups. Participants performed 12-week ECC or CONC training, 2–3 sessions per week, 10 to 30 min per session. Before and after training, peak oxygen consumption, maximal power output (VO2peak and POmax), and time-to-exhaustion (TTE) tests were performed. Plasma antioxidant and oxidative markers, insulin resistance, lipid profile, and systemic inflammation markers were measured before and after training at rest. VO2peak, POmax and TTE remained unchanged after ECC and CONC. CONC induced an increase in antioxidants (p = 0.01), while ECC decreased antioxidant (p = 0.02) markers measured at rest. CONC induced lesser increase in oxidative stress following TTE (p = 0.04), and a decrease in insulin resistance (p = 0.0006) compared to baseline. These results suggest that CONC training induced an increase in insulin sensitivity, antioxidant capacity at rest, and lesser exercise-induced oxidative stress in patients with moderate COPD. © 2023 by the authors.
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    Editorial: Spotlight on aging: physiology, prevention, and management of skeletal muscle atrophy
    (Frontiers Media SA, 2023) Marzuca-Nassr, Gabriel Nasri; Peñailillo, Luis; Valladares-Ide, Denisse; Martinez-Huenchullan, Sergio; Curi, Rui; Hirabara, Sandro Massao; Vitzel, Kaio Fernando
    Introduction: Atrophy of skeletal muscle during aging is a subject of heightened interest for researchers, as the muscle tissue is an essential regulator of whole-body metabolism, bone health, fall prevention, cognitive function, and general wellbeing. Indeed, the precise role of skeletal muscle and strategies to prevent the loss of skeletal muscle mass in individuals aged 60 years or older have been reported (Marzuca-Nassr et al., 2020a; Marzuca-Nassr et al., 2023). For example, previous studies demonstrated that skeletal muscle atrophy caused by aging can be attenuated/prevented using appropriate therapeutic strategies, including different physical exercise modalities, nutritional supplementation, and medications (Marzuca-Nassr et al., 2020b; Cuyul-Vasquez et al., 2023). However, the most appropriate exercise, supplement, or medication, individually or in combination, remains undefined. Thus, identifying the most effective strategies to attenuate or reverse skeletal muscle atrophy in this particular population is crucial. Towards this goal, the Frontiers in Physiology Healthy Aging series Research Topic Spotlight on Aging: Physiology, Prevention, and Management of Skeletal Muscle Atrophy was created. We encouraged researchers investigating the physiology of skeletal muscle atrophy, with an emphasis on the following subjects: skeletal muscle architecture and mechanical properties in older individuals and/or exercise modalities, oral supplements, medications, or other therapeutic alternatives that prevent and/or manage skeletal muscle atrophy, to submit their Original Research, Systematic Review (with or without Meta-analysis), or any other article type within the scope of the journal, section, and Research Topic for consideration for publication in the Healthy Aging series. It is important to point out that the objective of this Research Topic is in line with the United Nations Decade of Healthy Aging (2021–2030) Sustainable Development Goals, #SDG3, #SDG10, and #SDG11, which collectively seek to improve lives of older people, their families, and communities. Below, we selected several examples of manuscripts that address some of these Research Topic subjects and provide future directions.