Examinando por Autor "Werner, E."

Mostrando 1 - 2 de 2
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    Ítem
    Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin
    (MDPI, 2017-06) Escobar, B.; Montenegro, I.; Villena, J.; Werner, E.; Godoy, P.; Olguín, Y.; Madrid, A.
    An efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.
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    Ítem
    Synthesis and antiproliferative activity of new cyclodiprenyl phenols against select cancer cell lines
    (MDPI AG, 2018-09) Said, B.; Montenegro, I.; Valenzuela, M.; Olguín, Y.; Caro, N.; Werner, E.; Godoy, P.; Villena, J.; Madrid, A.
    Six new cyclodiprenyl phenols were synthesized by direct coupling of perillyl alcohol and the appropriate phenol. Their structures were established by IR, HRMS and mainly NMR. Three human cancer cell lines-breast (MCF-7), prostate (PC-3) and colon (HT-29)-were used in antiproliferative assays, with daunorubicin and dunnione as positive controls. Results described in the article suggest that dihydroxylated compounds 2-4 and monohydroxylated compound 5 display selectivity against cancer cell lines, cytotoxicity, apoptosis induction, and mitochondrial membrane impairment capacity. Compound 2 was identified as the most effective of the series by displaying against all cancer cell lines a cytotoxicity close to dunnione antineoplastic agent, suggesting that the cyclodiprenyl phenols from perillyl alcohol deserve more extensive investigation of their potential medicinal applications. © 2018 by the authors.