Epigenetic pathways regulating bone homeostasis:Potential targeting for intervention of skeletal disorders

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dc.contributor.authorGordon, Jonathan A.R.
dc.contributor.authorMontecino, Martin A.
dc.contributor.authorAqeilan, Rami I.
dc.contributor.authorStein, Janet L.
dc.contributor.authorStein, Gary S.
dc.contributor.authorLian, Jane B.
dc.date.accessioned2023-01-03T15:21:07Z
dc.date.available2023-01-03T15:21:07Z
dc.date.issued2014
dc.descriptionIndexación: Scopuses
dc.description.abstractEpigenetic regulation utilizes different mechanisms to convey heritable traits to progeny cells that are independent of DNA sequence, including DNA silencing, posttranslational modifications of histone proteins, and the posttranscriptional modulation of RNA transcript levels by noncoding RNAs.Although long non-coding RNAs have recently emerged as important regulators of gene imprinting, their functions during osteogenesis are as yet unexplored.In contrast, microRNAs (miRNAs) are well characterized for their control of osteogenic and osteoclastic pathways; thus, further defining how gene regulatory networks essential for skeleton functions are coordinated and finely tuned through the activities of miRNAs.Roles of miRNAs are constantly expanding as new studies uncover associations with skeletal disorders.The distinct functions of epigenetic regulators and evidence for integrating their activities to control normal bone gene expression and bone disease will be presented.In addition, potential for using “signature miRNAs” to identify, manage, and therapeutically treat osteosarcoma will be discussed in this review. © Springer Science+Business Media New York 2014.es
dc.description.urihttps://link-springer-com.recursosbiblioteca.unab.cl/article/10.1007/s11914-014-0240-1
dc.identifier.doi10.1007/s11914-014-0240-1
dc.identifier.issn1544-1873
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/35765
dc.language.isoenes
dc.publisherCurrent Medicine Group LLC 1es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectDNAmethylationes
dc.subjectEpigenetic marks in bonees
dc.subjectHistonemodificationses
dc.subjectmiRNAes
dc.subjectOsteoblast regulationes
dc.subjectOsteosarcoma miRNAses
dc.titleEpigenetic pathways regulating bone homeostasis:Potential targeting for intervention of skeletal disorderses
dc.typeArtículoes
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Current Osteoporosis Reports Volume 12, Issue 4, Pages 496 - 5061 November 2014
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