Hemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoin

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dc.contributor.authorEscobar, B.
dc.contributor.authorMontenegro, I.
dc.contributor.authorVillena, J.
dc.contributor.authorWerner, E.
dc.contributor.authorGodoy, P.
dc.contributor.authorOlguín, Y.
dc.contributor.authorMadrid, A.
dc.date.accessioned2017-11-24T20:39:10Z
dc.date.available2017-11-24T20:39:10Z
dc.date.issued2017-06
dc.descriptionIndexación: Web of Science; Scopus.es_CL
dc.description.abstractAn efficient synthesis of a series of 4-oxyalkyl-isocordoin analogues (2–8) is reported for the first time. Their structures were confirmed by1H-NMR,13C-NMR, and HRMS. Their anti-oomycete activity was evaluated by mycelium and spores inhibition assay against two selected pathogenic oomycetes strains: Saprolegnia parasitica and Saprolegnia australis. The entire series of isocordoin derivatives (except compound 7) showed high inhibitory activity against these oomycete strains. Among them, compound 2 exhibited strong activity, with minimum inhibitory concentration (MIC) and minimum oomyceticidal concentration (MOC) values of 50 µg/mL and 75 µg/mL, respectively. The results showed that 4-oxyalkylated analogues of isocordoin could be potential anti-oomycete agents.es_CL
dc.description.urihttp://www.mdpi.com/1420-3049/22/6/968
dc.identifier.citationMolecules. Volume 22, Issue 6, June 2017, Article number 968es_CL
dc.identifier.issn1420-3049
dc.identifier.otherdoi:10.3390/molecules22060968
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/4747
dc.language.isoenes_CL
dc.publisherMDPIes_CL
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAnti-oomycete activityes_CL
dc.subjectIsocordoines_CL
dc.subjectOxyalkyl derivateses_CL
dc.subjectSaprolegnia sp.es_CL
dc.titleHemi-Synthesis and Anti-Oomycete Activity of Analogues of Isocordoines_CL
dc.typeArtículoes_CL
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