Identification of biomarkers for disease severity in nasopharyngeal secretions of infants with upper or lower respiratory tract viral infections
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Archivos
Fecha
2022-10
Profesor/a Guía
Facultad/escuela
Idioma
en
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Título del volumen
Editor
Oxford University Press
Nombre de Curso
Licencia CC
CC BY-NC 4.0 DEED
Atribución-NoComercial 4.0 Internacional
Licencia CC
https://creativecommons.org/licenses/by-nc/4.0/deed.es
Resumen
Lower respiratory tract infections (LRTIs) produced by viruses are the most frequent cause of morbidity and mortality in children younger than 5 years of age. The immune response triggered by viral infection can induce a strong inflammation in the airways and cytokines could be considered as biomarkers for disease severity as these molecules modulate the inflammatory response that defines the outcome of patients. Aiming to predict the severity of disease during respiratory tract infections, we conducted a 1-year follow-up observational study in infants who presented upper or lower respiratory tract infections caused by seasonal respiratory viruses. At the time of enrollment, nasopharyngeal swabs (NPS) were obtained from infants to measure mRNA expression and protein levels of IL-3, IL-8, IL-33, and thymic stromal lymphopoietin. While all cytokines significantly increased their protein levels in infants with upper and lower respiratory tract infections as compared to control infants, IL-33 and IL-8 showed a significant increase in respiratory syncytial virus (RSV)-infected patients with LRTI as compared to patients with upper respiratory tract infection. We also found higher viral loads of RSV-positive samples with a greater IL-8 response at the beginning of the symptoms. Data obtained in this study suggest that both IL-8 and IL-33 could be used as biomarkers for clinical severity for infants suffering from LRTIs caused by the RSV. © 2022 The Author(s). Published by Oxford University Press on behalf of the British Society for Immunology. All rights reserved.
Notas
Indexación: Scopus.
Palabras clave
Cytokines, Respiratory tract infection, RSV, Biomarkers, Child, Humans, Infant, Interleukin-3, Interleukin-33, Interleukin-8, Respiratory Syncytial Virus Infections, Respiratory Syncytial Viruses, RNA, Messenger, Severity of Illness Index, Viruses
Citación
Clinical and Experimental Immunology, Volume 210, Issue 1, Pages 68 - 78, October 2022
DOI
10.1093/cei/uxac083