Reduced microbial diversity of the nasopharyngeal microbiome in household contacts with latent tuberculosis infection

Vista sencilla de ítem
dc.contributor.authorRuiz-Tagle, Cinthya
dc.contributor.authorUgalde, Juan A.
dc.contributor.authorNaves, Rodrigo
dc.contributor.authorAraos, Rafael
dc.contributor.authorGarcía, Patricia
dc.contributor.authorBalcells, María Elvira
dc.date.accessioned2023-08-08T17:38:47Z
dc.date.available2023-08-08T17:38:47Z
dc.date.issued2023-12
dc.descriptionIndexación: Scopus.es
dc.description.abstractThe upper respiratory tract is an obliged pathway for respiratory pathogens and a healthy microbiota may support the host's mucosal immunity preventing infection. We analyzed the nasopharyngeal microbiome in tuberculosis household contacts (HHCs) and its association with latent tuberculosis infection (TBI). A prospective cohort of HHCs was established and latent TBI status was assessed by serial interferon-γ release assay (IGRA). Nasopharyngeal swabs collected at baseline were processed for 16S rRNA gene sequencing. The 82 participants included in the analysis were classified as: (a) non-TBI [IGRA negative at baseline and follow-up, no active TB (n = 31)], (b) pre-TBI [IGRA negative at baseline but converted to IGRA positive or developed active TB at follow-up (n = 16)], and (c) TBI [IGRA positive at enrollment (n = 35)]. Predominant phyla were Actinobacteriota, Proteobacteria, Firmicutes and Bacteroidota. TBI group had a lower alpha diversity compared to non-TBI (padj = 0.04) and pre-TBI (padj = 0.04). Only TBI and non-TBI had beta diversity differences (padj = 0.035). Core microbiomes’ had unique genera, and genus showed differential abundance among groups. HHCs with established latent TBI showed reduced nasopharyngeal microbial diversity with distinctive taxonomical composition. Whether a pre-existing microbiome feature favors, are a consequence, or protects against Mycobacterium tuberculosis needs further investigation. © 2023, The Author(s).es
dc.identifier.citationScientific Reports, Volume 13, Issue 1, December 2023, Article number 7301es
dc.identifier.doi10.1038/s41598-023-34052-8
dc.identifier.issn20452322
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/52319
dc.language.isoenes
dc.publisherNature Researches
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectHumanses
dc.subjectInterferon-gamma Release Testses
dc.subjectLatent Tuberculosises
dc.subjectMicrobiotaes
dc.subjectMycobacterium tuberculosises
dc.subjectProspective Studieses
dc.subjectRNA, Ribosomal, 16Ses
dc.subjectTuberculosises
dc.titleReduced microbial diversity of the nasopharyngeal microbiome in household contacts with latent tuberculosis infectiones
dc.typeArtículoes
Archivos
Bloque original
Mostrando 1 - 1 de 1
Miniatura
Nombre:
Reduced-microbial-diversity-of-the-nasopharyngeal-microbiome-in-household-contacts-with-latent-tuberculosis-infectionScientific-Reports.pdf
Tamaño:
2.3 MB
Formato:
Adobe Portable Document Format
Descripción:
TEXTO COMPLETO EN INGLÉS
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
Fac.CV - Artículos de Revista
Nodo ANID