Comparative Toxicity of Aquatic Per- and Polyfluoroalkyl Substance Exposure in Three Species of Amphibians

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dc.contributor.authorFlynn, R. Wesley
dc.contributor.authorHoover, Gary
dc.contributor.authorIacchetta, Michael
dc.contributor.authorGuffey, Samuel
dc.contributor.authorde Perre, Chloe
dc.contributor.authorHuerta, Belinda
dc.contributor.authorLi, Weiming
dc.contributor.authorHoverman, Jason T.
dc.contributor.authorLee, Linda
dc.contributor.authorSepúlveda, Maria S.
dc.date.accessioned2024-05-08T20:11:10Z
dc.date.available2024-05-08T20:11:10Z
dc.date.issued2022-06
dc.descriptionIndexación: Scopus.
dc.description.abstractPer- and polyfluoroalkyl substances (PFAS) are contaminants of concern due to their widespread occurrence in the environment, persistence, and potential to elicit a range of negative health effects. Per- and polyfluoroalkyl substances are regularly detected in surface waters, but their effects on many aquatic organisms are still poorly understood. Species with thyroid-dependent development, like amphibians, can be especially susceptible to PFAS effects on thyroid hormone regulation. We examined sublethal effects of aquatic exposure to four commonly detected PFAS on larval northern leopard frogs (Rana [Lithobates] pipiens), American toads (Anaxyrus americanus), and eastern tiger salamanders (Ambystoma tigrinum). Animals were exposed for 30 days (frogs and salamanders) or until metamorphosis (toads) to 10, 100, or 1000 μg/L of perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS), or 6:2 fluorotelomer sulfonate (6:2 FTS). We determined that chronic exposure to common PFAS can negatively affect amphibian body condition and development at concentrations as low as 10 µg/L. These effects were highly species dependent, with species having prolonged larval development (frogs and salamanders) being more sensitive to PFAS than more rapidly developing species (toads). Our results demonstrate that some species could experience sublethal effects at sites with surface waters highly affected by PFAS. Our results also indicate that evaluating PFAS toxicity using a single species may not be sufficient for accurate amphibian risk assessment. Future studies are needed to determine whether these differences in susceptibility can be predicted from species' life histories and whether more commonly occurring environmental levels of PFAS could affect amphibians. Environ Toxicol Chem 2022;41:1407–1415. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.
dc.description.urihttps://setac-onlinelibrary-wiley-com.recursosbiblioteca.unab.cl/doi/10.1002/etc.5319
dc.identifier.citationEnvironmental Toxicology and Chemistry, Volume 41, Issue 6, Pages 1407 - 1415, June 2022
dc.identifier.doi10.1002/etc.5319
dc.identifier.issn0730-7268
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/56645
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectAmphibians
dc.subjectAquatic toxicology
dc.subjectPerfluoroalkyl substances
dc.titleComparative Toxicity of Aquatic Per- and Polyfluoroalkyl Substance Exposure in Three Species of Amphibians
dc.typeArtículo
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