Mitochondrial ASncmtRNA-1 and ASncmtRNA-2 as potent targets to inhibit tumor growth and metastasis in the RenCa murine renal adenocarcinoma model

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dc.contributor.authorBorgna, Vincenzo
dc.contributor.authorVillegas, Jaime
dc.contributor.authorBurzio, Verónica A.
dc.contributor.authorBelmar, Sebastián
dc.contributor.authorAraya, Mariela
dc.contributor.authorJeldes, Emanuel
dc.contributor.authorLobos-González, Lorena
dc.contributor.authorSilva, Verónica
dc.contributor.authorVillota, Claudio
dc.contributor.authorOliveira-Cruz, Luciana
dc.contributor.authorLopez, Constanza
dc.contributor.authorSocias, Teresa
dc.contributor.authorCastillo, Octavio
dc.contributor.authorBurzio, Luis O.
dc.date.accessioned2024-09-16T16:29:33Z
dc.date.available2024-09-16T16:29:33Z
dc.date.issued2017
dc.descriptionIndexación: Scopus
dc.description.abstractKnockdown of antisense noncoding mitochondrial RNAs (ASncmtRNAs) induces apoptosis in several human and mouse tumor cell lines, but not normal cells, suggesting this approach for a selective therapy against different types of cancer. Here we show that in vitro knockdown of murine ASncmtRNAs induces apoptotic death of mouse renal adenocarcinoma RenCa cells, but not normal murine kidney epithelial cells. In a syngeneic subcutaneous RenCa model, treatment delayed and even reversed tumor growth. Since the subcutaneous model does not reflect the natural microenviroment of renal cancer, we used an orthotopic model of RenCa cells inoculated under the renal capsule. These studies showed inhibition of tumor growth and metastasis. Direct metastasis assessment by tail vein injection of RenCa cells also showed a drastic reduction in lung metastatic nodules. In vivo treatment reduces survivin, N-cadherin and P-cadherin levels, providing a molecular basis for metastasis inhibition. In consequence, the treatment significantly enhanced mouse survival in these models. Our results suggest that the ASncmtRNAs could be potent and selective targets for therapy against human renal cell carcinoma. © Borgna et al.
dc.identifier.citationOncotarget Volume 8, Issue 27, Pages 43692 - 437082017
dc.identifier.issn1949-2553
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/60234
dc.language.isoen
dc.publisherImpact Journals LLC
dc.subjectAntisense therapy
dc.subjectMitochondria
dc.subjectMurine renal cancer
dc.subjectNcRNA
dc.titleMitochondrial ASncmtRNA-1 and ASncmtRNA-2 as potent targets to inhibit tumor growth and metastasis in the RenCa murine renal adenocarcinoma model
dc.typeArtículo
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