Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjogren's syndrome:: association with mononuclear cell infiltration

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dc.contributor.authorMolina, C
dc.contributor.authorAlliende, C
dc.contributor.authorAguilera, S
dc.contributor.authorKwon, YJ
dc.contributor.authorLeyton, L
dc.contributor.authorMartínez, B
dc.contributor.authorLeyton, C
dc.contributor.authorPérez, P
dc.contributor.authorGonzález, MJ
dc.date.accessioned2024-07-04T16:42:12Z
dc.date.available2024-07-04T16:42:12Z
dc.date.issued2006-02-01
dc.descriptionINDEXACIÓN: WEB OF SCIENCE.
dc.description.abstractObjective: To study the expression of laminin and type IV collagen as biomarkers of the organisation of the basal lamina of acini and ducts in labial salivary glands from patients with Sjogren's syndrome, and to relate this organisation to inflammatory cell invasion of acini and ducts. Methods: Immunohistochemistry for laminin and type IV collagen was undertaken on sections of labial salivary glands from 30 patients with Sjogren's syndrome, 10 control subjects, and 24 controls with chronic sialoadenitis. Immunohistochemistry reaction, alterations to cell morphology, and the presence of inflammatory cells in acini and ducts were evaluated and scored using a semiquantitative method. Results: Changes in the expression of laminin and type IV collagen in the basal lamina of acini and ducts of labial salivary glands from patients with Sjogren's syndrome were more pronounced than in labial salivary glands from control groups. A remarkable characteristic was the disorganisation of the basal lamina in the labial salivary glands in Sjogren's syndrome. The pattern of immunoreactivity of the basal lamina of other structures (for example, blood vessels) did not change. In Sjogren's syndrome, invasion of cytotoxic T lymphocytes was only observed in acini and ducts which had a disorganised basal lamina. Conclusions: The high state of disorganisation of the basal lamina of acini and ducts could allow invasion of cytotoxic T lymphocytes in Sjogren's syndrome, contributing to cell death and ductal hyperplasia.
dc.identifier.citationANNALS OF THE RHEUMATIC DISEASES, Volume 65, Issue 2, Page 178-183
dc.identifier.doi10.1136/ard.2004.033837
dc.identifier.issn0003-4967
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/58195
dc.language.isoen
dc.publisherBMJ PUBLISHING GROUP
dc.rights.licenseCC BY-NC 4.0 ATRIBUCIÓN-NOCOMERCIAL 4.0 INTERNACIONAL Deed
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/deed.es
dc.subjectMESSENGER-RNA EXPRESSION
dc.subjectNOD MOUSE MODEL
dc.subjectMATRIX METALLOPROTEINASES
dc.subjectLYMPHOCYTIC INFILTRATION
dc.subjectTRANSCRIPTION FACTORS
dc.subjectPATHOGENESIS
dc.subjectDESTRUCTION
dc.subjectMECHANISMS
dc.subjectARTHRITIS
dc.subjectPROTEINS
dc.titleBasal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjogren's syndrome:: association with mononuclear cell infiltration
dc.typeArtículo
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