Mobile genetic elements drive the multidrug resistance and spread of Salmonella serotypes along a poultry meat production line

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dc.contributor.authorKrüger, Gabriel I.
dc.contributor.authorPardo-Esté, Coral
dc.contributor.authorZepeda, Phillippi
dc.contributor.authorOlivares-Pacheco, Jorge
dc.contributor.authorGalleguillos, Nicolas
dc.contributor.authorSuarez, Marcia
dc.contributor.authorCastro-Severyn, Juan
dc.contributor.authorAlvarez-Thon, Luis
dc.contributor.authorTello, Mario
dc.contributor.authorValdes, Jorge H.
dc.contributor.authorSaavedra, Claudia P.
dc.date.accessioned2023-04-17T18:19:32Z
dc.date.available2023-04-17T18:19:32Z
dc.date.issued2023-03
dc.descriptionIndexación: Scopuses
dc.description.abstractThe presence of mobile genetic elements in Salmonella isolated from a chicken farm constitutes a potential risk for the appearance of emerging bacteria present in the food industry. These elements contribute to increased pathogenicity and antimicrobial resistance through genes that are related to the formation of biofilms and resistance genes contained in plasmids, integrons, and transposons. One hundred and thirty-three Salmonella isolates from different stages of the production line, such as feed manufacturing, hatchery, broiler farm, poultry farm, and slaughterhouse, were identified, serotyped and sequenced. The most predominant serotype was Salmonella Infantis. Phylogenetic analyses demonstrated that the diversity and spread of strains in the pipeline are serotype-independent, and that isolates belonging to the same serotype are very closely related genetically. On the other hand, Salmonella Infantis isolates carried the pESI IncFIB plasmid harboring a wide variety of resistance genes, all linked to mobile genetic elements, and among carriers of these plasmids, the antibiograms showed differences in resistance profiles and this linked to a variety in plasmid structure, similarly observed in the diversity of Salmonella Heidelberg isolates carrying the IncI1-Iα plasmid. Mobile genetic elements encoding resistance and virulence genes also contributed to the differences in gene content. Antibiotic resistance genotypes were matched closely by the resistance phenotypes, with high frequency of tetracycline, aminoglycosides, and cephalosporins resistance. In conclusion, the contamination in the poultry industry is described throughout the entire production line, with mobile genetic elements leading to multi-drug resistant bacteria, thus promoting survival when challenged with various antimicrobial compounds. Copyright © 2023 Krüger, Pardo-Esté, Zepeda, Olivares-Pacheco, Galleguillos, Suarez, Castro-Severyn, Alvarez-Thon, Tello, Valdes and Saavedra.es
dc.description.urihttps://www.frontiersin.org/articles/10.3389/fmicb.2023.1072793/full
dc.identifier.citationFrontiers in Volume 14 March 2023 Article number 1072793es
dc.identifier.doi10.3389/fmicb.2023.1072793
dc.identifier.issn1664-302X
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/48618
dc.language.isoenes
dc.publisherFrontiers Media S.A.es
dc.rights.licenseAtribución 4.0 Internacional (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAntimicrobial resistancees
dc.subjectGenomicses
dc.subjectMobile genetics elementses
dc.subjectPoultryes
dc.subjectSalmonellaes
dc.titleMobile genetic elements drive the multidrug resistance and spread of Salmonella serotypes along a poultry meat production linees
dc.typeArtículoes
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