Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases

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dc.contributor.authorOrellana, JA
dc.contributor.authorRetamal, MA
dc.contributor.authorMoraga-Amaro, R
dc.contributor.authorStehberg, J
dc.date.accessioned2017-01-27T16:19:16Z
dc.date.available2017-01-27T16:19:16Z
dc.date.issued2016-07
dc.descriptionIndexación: Web of Sciencees
dc.description.abstractUnder physiological conditions, astroglial hemichannels and pannexons allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory. However, recent evidence suggests that under pathological conditions, they may be central in the development of various neurodegenerative diseases. Here we review current literature on the role of astroglial hemichannels and pannexons in memory, stress and the development of neurodegenerative diseases, and propose that they are not only crucial for normal brain function, including memory, but also a potential target for the treatment of neurodegenerative diseaseses
dc.description.urihttp://journal.frontiersin.org/article/10.3389/fnint.2016.00026/full
dc.identifier.citationFront. Integr. Neurosci., 20 July 2016es
dc.identifier.issn1662-5145
dc.identifier.otherdoi.org/10.3389/fnint.2016.00026
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/2782
dc.language.isoenes
dc.publisherFRONTIERS MEDIA SAes
dc.subjectConnexin hemichannelses
dc.subjectCx hemichannelses
dc.subjectConnexin 43es
dc.subjectPannexines
dc.subjectAstrocyteses
dc.subjectMemoryes
dc.titleRole of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseaseses
dc.typeArtículoes
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