Efficacy of Multivalent, Cochleate-Based Vaccine against Salmonella Infantis, S. Enteritidis and S. Typhimurium in Laying Hens

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dc.contributor.authorSáenz, L.
dc.contributor.authorGuzmán, M.
dc.contributor.authorVidal, S.
dc.contributor.authorCaruffo, M.
dc.contributor.authorSiel, D.
dc.contributor.authorZayas, C.
dc.contributor.authorParedes, R.
dc.contributor.authorValenzuela, C.
dc.contributor.authorHidalgo, H.
dc.contributor.authorPérez, O.
dc.contributor.authorLapierre, L.
dc.date.accessioned2022-08-05T13:01:27Z
dc.date.available2022-08-05T13:01:27Z
dc.date.issued2022-02
dc.descriptionIndexación: Scopus.es
dc.description.abstractSalmonella enterica is an important foodborne pathogen. Commercial poultry are the main reservoirs of Salmonella enterica, leading to the contamination of food and outbreaks in humans. The vaccination of chickens is one of the most important strategies to reduce the number of Salmonella in poultry farms. Unfortunately, commercial vaccines have not been fully effective in controlling the spread and do not contain all the Salmonella serovars that circulate on farms. In this study, we evaluate a new, cochleate-based, trivalent injectable vaccine against S. Enteritidis, S. Typhimurium and S. Infantis, describing the vaccine security, capacity to induce specific anti-Salmonella serovar IgY and the gene expression of immune markers related to CD4 and CD8 T-cell-mediated immunity. Efficacy was evaluated through oral challenges performed separately for each Salmonella serotype. The efficacy and safety of the trivalent vaccine was proven under controlled conditions. The vaccine has no local or systemic reactions or adverse effects on poultry performance related to the vaccine. The vaccine provided significantly increased serum IgY titer levels, significantly reduced Salmonella CFU/g present in the cecum and an increased CD4+/CD8+ ratio in vaccinated animals when challenged with S. Infantis, S. Enteritidis and S. Typhimurium. These results indicate that this new trivalent vaccine does not generate adverse effects in poultry and produces an increase in neutralizing antibodies against the three Salmonella serovars.es
dc.description.urihttps://www.mdpi.com/2076-393X/10/2/226
dc.identifier.citationVaccines, Volume 10, Issue 2, February 2022, Article number 226es
dc.identifier.doi10.3390/vaccines10020226
dc.identifier.issn2076-393X
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/23454
dc.language.isoenes
dc.publisherMDPIes
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://www.mdpi.com/openaccess
dc.subjectCochleatees
dc.subjectELISAes
dc.subjectPoultryes
dc.subjectSalmonella Infantises
dc.subjectVaccinees
dc.titleEfficacy of Multivalent, Cochleate-Based Vaccine against Salmonella Infantis, S. Enteritidis and S. Typhimurium in Laying Henses
dc.typeArtículoes
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