Pharmacokinetic assessment of vancomycin loading dose in critically ill patients

Vista sencilla de ítem
dc.contributor.authorÁlvarez, Osvaldo
dc.contributor.authorPlaza-Plaza, Jose Cristian
dc.contributor.authorRamirez, Manuel
dc.contributor.authorPeralta, Alexis
dc.contributor.authorAmador, Cristián A.
dc.contributor.authorAmador, Roberto
dc.date.accessioned2024-04-22T12:51:42Z
dc.date.available2024-04-22T12:51:42Z
dc.date.issued2017-08
dc.descriptionIndexación: Scopus
dc.description.abstractThe vancomycin loading dose (LD) of 25 to 30 mg/kg is a frequently practiced strategy to achieve effective concentrations from the first-treatment dose. However, considering only the body weight for dosing might be inadequate in critically ill patients due to pharmacokinetics changes. We sought to assess achieving optimal trough serum levels of vancomycin and AUC0–24/MIC in the first 24 h of treatment by using an LD based on population pharmacokinetic parameters of critically ill patients. We performed a concurrent cohort study over 22 months of patients with severe sepsis who received intravenous vancomycin. The patients were treated with three different strategies to initiate vancomycin: without an LD (group A), with an LD of 25 to 30 mg/kg (group B), and with an LD based on population pharmacokinetic parameters of the critically ill patient (group C). An optimal trough serum concentration was achieved in 5, 9, and 83% of patients in groups A, B, and C, respectively. The number of patients that reached optimal AUC0–24 was 2 of 18 (11%), 5 of 11 (46%), and 11 of 12 (92%) in groups A, B, and C, respectively. The statistical analysis for both parameters revealed significant differences in group C with respect to other groups. The administration of the LD calculated from population pharmacokinetic parameters from the beginning of therapy is a more efficient strategy to obtain adequate trough serum concentrations and AUC0–24/MIC in critical patients. © 2017 American Society for Microbiology. All Rights Reserved.
dc.description.urihttps://journals-asm-org.recursosbiblioteca.unab.cl/doi/10.1128/aac.00280-17
dc.identifier.citationAntimicrobial Agents and Chemotherapy Volume 61, Issue 8August 2017 Article number e00280
dc.identifier.doi10.1128/AAC.00280-17
dc.identifier.issn0066-4804
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/56217
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.rights.licenseCC BY 4.0 DEED Atribución 4.0 Internacional
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectCritical care
dc.subjectPharmacokinetics
dc.subjectVancomycin
dc.titlePharmacokinetic assessment of vancomycin loading dose in critically ill patients
dc.typeArtículo
Archivos
Bloque original
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
TEXTO EN INGLES
Tamaño:
597.69 KB
Formato:
Adobe Portable Document Format
Descargar
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descripción:
Descargar
Colecciones
FM - Artículos de Revista