Pathophysiological, immunological, and inflammatory features of long COVID

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dc.contributor.authorBohmwald, Karen
dc.contributor.authorDiethelm-Varela, Benjamín
dc.contributor.authorRodríguez-Guilarte, Linmar
dc.contributor.authorRivera, Thomas
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorGonzález, Pablo A.
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-05-29T14:53:34Z
dc.date.available2024-05-29T14:53:34Z
dc.date.issued2024
dc.descriptionIndexación: Scopus.
dc.description.abstractThe COVID-19 pandemic continues to cause severe global disruption, resulting in significant excess mortality, overwhelming healthcare systems, and imposing substantial social and economic burdens on nations. While most of the attention and therapeutic efforts have concentrated on the acute phase of the disease, a notable proportion of survivors experience persistent symptoms post-infection clearance. This diverse set of symptoms, loosely categorized as long COVID, presents a potential additional public health crisis. It is estimated that 1 in 5 COVID-19 survivors exhibit clinical manifestations consistent with long COVID. Despite this prevalence, the mechanisms and pathophysiology of long COVID remain poorly understood. Alarmingly, evidence suggests that a significant proportion of cases within this clinical condition develop debilitating or disabling symptoms. Hence, urgent priority should be given to further studies on this condition to equip global public health systems for its management. This review provides an overview of available information on this emerging clinical condition, focusing on the affected individuals’ epidemiology, pathophysiological mechanisms, and immunological and inflammatory profiles.
dc.description.urihttps://www-scopus-com.recursosbiblioteca.unab.cl/record/display.uri?eid=2-s2.0-85187727668&origin=resultslist&sort=plf-f&src=s&nlo=&nlr=&nls=&sid=c2d0ec09d0089c6c9ad05555b13bd782&sot=aff&sdt=cl&cluster=scofreetoread%2c%22all%22%2ct&sl=61&s=AF-ID%28%22Universidad+Andr%c3%a9s+Bello%22+60002636%29+AND+SUBJAREA%28IMMU%29&relpos=18&citeCnt=1&searchTerm=
dc.identifier.citationFrontiers in Immunology Open Access Volume 152024 Article number 1341600
dc.identifier.doi10.3389/fimmu.2024.1341600
dc.identifier.issn16643224
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/57194
dc.language.isoen
dc.publisherFrontiers Media SA
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.subjectepidemiology
dc.subjectimmune response
dc.subjectlong Covid
dc.subjectneurological alterations
dc.subjectpathophysiology
dc.subjectSARS-CoV-2
dc.titlePathophysiological, immunological, and inflammatory features of long COVID
dc.typeArtículo
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