Progression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilation

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dc.contributor.authorHurtado, Daniel E.
dc.contributor.authorErranz, Benjamín
dc.contributor.authorLillo, Felipe
dc.contributor.authorSarabia-Vallejos, Mauricio
dc.contributor.authorIturrieta, Pablo
dc.contributor.authorMorales, Felipe
dc.contributor.authorBlaha, Katherine
dc.contributor.authorMedina, Tania
dc.contributor.authorDiaz, Franco
dc.contributor.authorCruces, Pablo
dc.date.accessioned2023-04-24T14:34:21Z
dc.date.available2023-04-24T14:34:21Z
dc.date.issued2020-12
dc.descriptionIndexación: Scopus.es
dc.description.abstractBackground: Protective mechanical ventilation (MV) aims at limiting global lung deformation and has been associ‑ ated with better clinical outcomes in acute respiratory distress syndrome (ARDS) patients. In ARDS lungs without MV support, the mechanisms and evolution of lung tissue deformation remain understudied. In this work, we quantify the progression and heterogeneity of regional strain in injured lungs under spontaneous breathing and under MV. Methods: Lung injury was induced by lung lavage in murine subjects, followed by 3 h of spontaneous breathing (SB-group) or 3 h of low Vt mechanical ventilation (MV-group). Micro-CT images were acquired in all subjects at the beginning and at the end of the ventilation stage following induction of lung injury. Regional strain, strain progres‑ sion and strain heterogeneity were computed from image-based biomechanical analysis. Three-dimensional regional strain maps were constructed, from which a region-of-interest (ROI) analysis was performed for the regional strain, the strain progression, and the strain heterogeneity. Results: After 3 h of ventilation, regional strain levels were signifcantly higher in 43.7% of the ROIs in the SB-group. Signifcant increase in regional strain was found in 1.2% of the ROIs in the MV-group. Progression of regional strain was found in 100% of the ROIs in the SB-group, whereas the MV-group displayed strain progression in 1.2% of the ROIs. Progression in regional strain heterogeneity was found in 23.4% of the ROIs in the SB-group, while the MV-group resulted in 4.7% of the ROIs showing signifcant changes. Deformation progression is concurrent with an increase of non-aerated compartment in SB-group (from 13.3%±1.6% to 37.5%±3.1%), being higher in ventral regions of the lung. Conclusions: Spontaneous breathing in lung injury promotes regional strain and strain heterogeneity progression. In contrast, low Vt MV prevents regional strain and heterogeneity progression in injured lungs.es
dc.description.urihttps://annalsofintensivecare.springeropen.com/articles/10.1186/s13613-020-00725-0
dc.identifier.citationAnnals of Intensive Care. Volume 10, Issue 11 December 2020 Article number 107es
dc.identifier.doi10.1186/s13613-020-00725-0
dc.identifier.issn2110-5820
dc.identifier.urihttps://repositorio.unab.cl/xmlui/handle/ria/48850
dc.language.isoenes
dc.publisherSpringeres
dc.rights.licenseAtribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.es
dc.subjectAcute Lung Injuryes
dc.subjectSpontaneous Breathinges
dc.subjectMechanical Ventilationes
dc.subjectLung Straines
dc.subjectLung Heterogeneityes
dc.subjectImage-Based Biomechanical Analysises
dc.titleProgression of regional lung strain and heterogeneity in lung injury: assessing the evolution under spontaneous breathing and mechanical ventilationes
dc.typeArtículoes
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