High diversity, novel genotypes, and vertical transmission of hemotropic Mycoplasma in micromammals

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dc.contributor.authorMillan, J.
dc.contributor.authorMartín-Maldonado, B.
dc.contributor.authorRodríguez-Pastor, R.
dc.contributor.authorMartínezPadilla, J.
dc.contributor.authorEsperon, F.
dc.date.accessioned2024-09-12T00:40:11Z
dc.date.available2024-09-12T00:40:11Z
dc.date.issued2024-04
dc.descriptionTEXTO COMPLETO EN INGLÉS
dc.description.abstractHemotropic mycoplasmas (hemoplasmas) are emerging zoonotic pathogens. Micromammals have received little attention as hosts for hemoplasmas despite their ubiquitous presence, high population abundances, and close association with humans. A PCR protocol targeting a fragment of the 16 S rRNA gene and direct sequencing in blood samples of 189 adult specimens and 35 fetuses belonging to three species of Eulipotyphla (shrews) and seven species of Rodentia, captured in three ecologically diverse habitats in North-Eastern Spain (Steppe, High Mountain, Mediterranean) yielded and occurrence of 26%, including 36% of 39 shrews and 23% of 150 rodents. Sequencing revealed the presence of 14 nucleotide sequence types (ntST) among the 56 readable sequences. In general, each ntST was associated with a given host species, although in some cases, the same ntST was sequenced in different species (chiefly rodents). Most ntST were closely related to rodent and/or bat hemoplasmas, but one was identical with Mycoplasma haemocanis/haemofelis, and others can be considered novel genotypes. High sequence diversity was detected in rodents, whereas in the white-toothed shrew (Crocidura russula), 9/11 sequences from two distant areas were identical. Phylogenetic and network analyses classified our sequences in different clades including hemoplasmas of rodents, carnivores, bats, and humans. Twelve of the fetuses (34.2%) of 9/12 litters (75.0%) of shrews and rodents were hemoplasma-positive, indicating frequent vertical transmission. Our study contributes to expanding our knowledge about the distribution, diversity, and transmission of hemoplasmas.
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S0147957124000286
dc.identifier.citationComparative Immunology, Microbiology and Infectious Diseases, Volume 107 , April 2024, 102151
dc.identifier.doihttps://doi.org/10.1016/j.cimid.2024.102151
dc.identifier.issn1878-1667
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/60130
dc.language.isoen
dc.publisherElsevier
dc.rights.licenseAttribution 4.0 International
dc.subjectAragon
dc.subjectCatalonia
dc.subjectIberian Peninsula
dc.subjectInsectivora
dc.subjectMollicutes
dc.subjectMycoplasma sp.
dc.titleHigh diversity, novel genotypes, and vertical transmission of hemotropic Mycoplasma in micromammals
dc.typeArtículo
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