Humoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults

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dc.contributor.authorMéndez, Constanza
dc.contributor.authorPeñaloza, Hernán F.
dc.contributor.authorSchultz, Bárbara M.
dc.contributor.authorPiña-Iturbe, Alejandro
dc.contributor.authorRíos, Mariana
dc.contributor.authorMoreno-Tapia, Daniela
dc.contributor.authorPereira-Sánchez, Patricia
dc.contributor.authorLeighton, Diane
dc.contributor.authorOrellana, Claudia
dc.contributor.authorCovarrubias, Consuelo
dc.contributor.authorGálvez, Nicolás M.S.
dc.contributor.authorSoto, Jorge A.
dc.contributor.authorDuarte, Luisa F.
dc.contributor.authorRivera-Pérez, Daniela
dc.contributor.authorVázquez, Yaneisi
dc.contributor.authorCabrera, Alex
dc.contributor.authorBustos, Sergio
dc.contributor.authorIturriaga, Carolina
dc.contributor.authorUrzua, Marcela
dc.contributor.authorNavarrete, María S.
dc.contributor.authorRojas, Álvaro
dc.contributor.authorFasce, Rodrigo A.
dc.contributor.authorFernández, Jorge
dc.contributor.authorMora, Judith
dc.contributor.authorRamírez, Eugenio
dc.contributor.authorGaete-Argel, Aracelly
dc.contributor.authorAcevedo, Mónica
dc.contributor.authorValiente-Echeverría, Fernando
dc.contributor.authorSoto-Rifo, Ricardo
dc.contributor.authorWeiskopf, Daniela
dc.contributor.authorGrifoni, Alba
dc.contributor.authorSette, Alessandro
dc.contributor.authorZeng, Gang
dc.contributor.authorMeng, Weining
dc.contributor.authorDel Río, Constanza
dc.contributor.authorDel Pino, Dinely
dc.contributor.authorAguirre, Natalia
dc.contributor.authorSalinas, Grecia
dc.contributor.authorVega, Franco
dc.contributor.authorSalgado, Acsa
dc.contributor.authorQuinteros, Thomas
dc.contributor.authorOrtiz, Marlene
dc.contributor.authorPuente, Marcela
dc.contributor.authorMuñoz, Alma
dc.contributor.authorAstudillo, Patricio
dc.contributor.authorLe Corre, Nicole
dc.contributor.authorPotin, Marcela
dc.contributor.authorCatalán, Juan
dc.contributor.authorPeralta, Melan
dc.contributor.authorZamanillo, Consuelo
dc.contributor.authorKeller, Nicole
dc.contributor.authorFernández, Rocío
dc.contributor.authorAljaro, Sofía
dc.contributor.authorLópez, Sofía
dc.contributor.authorGonzález, José Tomás
dc.contributor.authorWeil, Tania
dc.contributor.authorOpazo, Luz
dc.contributor.authorMuñoz, Paula
dc.contributor.authorEstay, Inés
dc.contributor.authorCantillana, Miguel
dc.contributor.authorCarrera, Liliana
dc.contributor.authorMasalleras, Matías
dc.contributor.authorGuzmán, Paula
dc.contributor.authorAguirre, Francisca
dc.contributor.authorCortés, Aarón
dc.contributor.authorBátiz, Luis Federico
dc.contributor.authorPérez, Javiera
dc.contributor.authorApablaza, Karen
dc.contributor.authorYates, Lorena
dc.contributor.authorValdés, María de los Ángeles
dc.contributor.authorHurtado, Bernardita
dc.contributor.authorVenteneul, Veronique
dc.contributor.authorAstorga, Constanza
dc.contributor.authorMuñoz-Venturelli, Paula
dc.contributor.authorVial, Pablo A.
dc.contributor.authorSchilling, Andrea
dc.contributor.authorPavez, Daniela
dc.contributor.authorPérez, Inia
dc.contributor.authorRiviotta, Amy
dc.contributor.authorGonzález, Francisca
dc.contributor.authorUrrutia, Francisca
dc.contributor.authorDel Río, Alejandra
dc.contributor.authorAsenjo, Claudia
dc.contributor.authorVargas, Bárbara
dc.contributor.authorCastro, Francisca
dc.contributor.authorAcuña, Alejandra
dc.contributor.authorGuzmán, Javiera
dc.contributor.authorAstudillo, Camila
dc.contributor.authorPérez, Carlos M.
dc.contributor.authorEspinoza, Pilar
dc.contributor.authorMartínez, Andrea
dc.contributor.authorArancibia, Marcela
dc.contributor.authorRomero, Harold
dc.contributor.authorBustamante, Cecilia
dc.contributor.authorPérez, María Loreto
dc.contributor.authorUribe, Natalia
dc.contributor.authorSilva, Viviana
dc.contributor.authorMorice, Bernardita
dc.contributor.authorPérez, Marco
dc.contributor.authorGonzález, Marcela
dc.contributor.authorJensen, Werner
dc.contributor.authorPasten, Claudia
dc.contributor.authorAguilera, M. Fernanda
dc.contributor.authorMartínez, Nataly
dc.contributor.authorMolina, Camila
dc.contributor.authorArrieta, Sebastián
dc.contributor.authorLópez, Begoña
dc.contributor.authorOrtiz, Claudia
dc.contributor.authorEscobar, Macarena
dc.contributor.authorBustamante, Camila
dc.contributor.authorEspinoza, Marcia
dc.contributor.authorPardo, Angela
dc.contributor.authorCarrasco, Alison
dc.contributor.authorMontes, Miguel
dc.contributor.authorSaldías, Macarena
dc.contributor.authorGutiérrez, Natalia
dc.contributor.authorSánchez, Juliette
dc.contributor.authorFuentes, Daniela
dc.contributor.authorCalvo, Yolanda
dc.contributor.authorCepeda, Mariela
dc.contributor.authorLemus, Rosario
dc.contributor.authorSuárez, Muriel
dc.contributor.authorArmijo, Mercedes
dc.contributor.authorMonsalves, Shirley
dc.contributor.authorMarucich, Constance
dc.contributor.authorCornejo, Cecilia
dc.contributor.authorAcosta, Ángela
dc.contributor.authorPrado, Xaviera
dc.contributor.authorYáñez, Francisca
dc.contributor.authorBarroeta, Marisol
dc.contributor.authorLópez, Claudia
dc.contributor.authorDonato, Paulina
dc.contributor.authorLasso, Martin
dc.contributor.authorIturrieta, María
dc.contributor.authorGiraldo, Juan
dc.contributor.authorGutiérrez, Francisco
dc.contributor.authorAcuña, María
dc.contributor.authorCascone, Ada
dc.contributor.authorRojas, Raymundo
dc.contributor.authorSepúlveda, Camila
dc.contributor.authorContreras, Mario
dc.contributor.authorCampisto, Yessica
dc.contributor.authorGonzález, Pablo A.
dc.contributor.authorQuizhpi, Zoila
dc.contributor.authorLópez, Mariella
dc.contributor.authorPizzeghello, Vania
dc.contributor.authorSilva, Stephannie
dc.contributor.authorGonzález-Aramundiz, José V.
dc.contributor.authorAbarca, Katia
dc.contributor.authorMelo-González, Felipe
dc.contributor.authorBueno, Susan M.
dc.contributor.authorKalergis, Alexis M.
dc.date.accessioned2024-10-17T12:50:37Z
dc.date.available2024-10-17T12:50:37Z
dc.date.issued2023-05
dc.descriptionIndexación: Scopus
dc.description.abstractBackground: The Omicron variant has challenged the control of the COVID-19 pandemic due to its immuno-evasive properties. The administration of a booster dose of a SARS-CoV-2 vaccine showed positive effects in the immunogenicity against SARS-CoV-2, effect that is even enhanced after the administration of a second booster. Methods: During a phase-3 clinical trial, we evaluated the effect of a second booster of CoronaVac®, an inactivated vaccine administered 6 months after the first booster, in the neutralization of SARS-CoV-2 (n = 87). In parallel, cellular immunity (n = 45) was analyzed in stimulated peripheral mononuclear cells by flow cytometry and ELISPOT. Findings: Although a 2.5-fold increase in neutralization of the ancestral SARS-CoV-2 was observed after the second booster when compared with prior its administration (Geometric mean units p < 0.0001; Geometric mean titer p = 0.0002), a poor neutralization against the Omicron variant was detected. Additionally, the activation of specific CD4+ T lymphocytes remained stable after the second booster and, importantly, equivalent activation of CD4+ T lymphocytes against the Omicron variant and the ancestral SARS-CoV-2 were found. Interpretation: Although the neutralizing response against the Omicron variant after the second booster of CoronaVac® was slightly increased, these levels are far from those observed against the ancestral SARS-CoV-2 and could most likely fail to neutralize the virus. In contrast, a robust CD4+T cell response may confer protection against the Omicron variant. Funding: The Ministry of Health, Government of Chile, the Confederation of Production and Commerce, Chile and SINOVAC Biotech. NIH NIAID. The Millennium Institute on Immunology and Immunotherapy. © 2023 The Author(s)
dc.description.urihttps://www-sciencedirect-com.recursosbiblioteca.unab.cl/science/article/pii/S2352396423001287?via%3Dihub
dc.identifier.citationeBioMedicine. Volume 91. May 2023. Article number 104563
dc.identifier.doi10.1016/j.ebiom.2023.104563
dc.identifier.issn2352-3964
dc.identifier.urihttps://repositorio.unab.cl/handle/ria/61336
dc.language.isoen
dc.publisherElsevier B.V.
dc.rights.licenseCC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivatives 4.0 International Deed
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCellular Immunity
dc.subjectCoronaVac®
dc.subjectHumoral Immunity
dc.subjectOmicron Variant
dc.subjectSARS-CoV-2
dc.subjectSecond Booster Dose
dc.titleHumoral and cellular response induced by a second booster of an inactivated SARS-CoV-2 vaccine in adults
dc.typeArtículo
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