Entry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infection

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dc.contributor.authorCastro-Córdova, P.
dc.contributor.authorMora-Uribe, P.
dc.contributor.authorReyes-Ramírez, R.
dc.contributor.authorCofré-Araneda, G.
dc.contributor.authorOrozco-Aguilar, J.
dc.contributor.authorBrito-Silva, C.
dc.contributor.authorMendoza-León, M.J.
dc.contributor.authorKuehne, S.A.
dc.contributor.authorMinton, N.P.
dc.contributor.authorPizarro-Guajardo, M.
dc.contributor.authorParedes-Sabja, D.
dc.date.accessioned2021-05-11T14:03:34Z
dc.date.available2021-05-11T14:03:34Z
dc.date.issued2021-12
dc.descriptionIndexación Scopuses
dc.description.abstractClostridioides difficile spores produced during infection are important for the recurrence of the disease. Here, we show that C. difficile spores gain entry into the intestinal mucosa via pathways dependent on host fibronectin-α5β1 and vitronectin-αvβ1. The exosporium protein BclA3, on the spore surface, is required for both entry pathways. Deletion of the bclA3 gene in C. difficile, or pharmacological inhibition of endocytosis using nystatin, leads to reduced entry into the intestinal mucosa and reduced recurrence of the disease in a mouse model. Our findings indicate that C. difficile spore entry into the intestinal barrier can contribute to spore persistence and infection recurrence, and suggest potential avenues for new therapies. © 2021, The Author(s).es
dc.description.urihttps://www-nature-com.recursosbiblioteca.unab.cl/articles/s41467-021-21355-5
dc.identifier.citationNature Communications Volume 12, Issue 1, December 2021, Article number 1140es
dc.identifier.doi10.1038/s41467-021-21355-5
dc.identifier.issn20411723
dc.identifier.urihttp://repositorio.unab.cl/xmlui/handle/ria/18824
dc.language.isoenes
dc.publisherNature Researches
dc.subjectPeptoclostridium Difficilees
dc.subjectClostridium Infectionses
dc.subjectPseudomembranous Enterocolitises
dc.titleEntry of spores into intestinal epithelial cells contributes to recurrence of Clostridioides difficile infectiones
dc.typeArtículoes
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